Frontline Science: Wnt/β-catenin pathway promotes early engraftment of fetal hematopoietic stem/progenitor cells

被引：12
作者：
Kwarteng, Edward O. [1 ]
Hetu-Arbour, Roxann [1 ]
Heinonen, Krista M. [1 ]
机构：
[1] Univ Quebec, Inst Natl Rech Sci, INRS Inst Armand Frappier, 531 Boul Prairies, Laval, PQ H7V 1B7, Canada
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2018年 / 103卷 / 03期
基金：
加拿大自然科学与工程研究理事会; 加拿大创新基金会;
关键词：
beta-catenin; bone marrow; development; fetal liver; hematopoietic stem cells; Wnt signaling; STEM-CELL; BETA-CATENIN; SELF-RENEWAL; PROGENITOR CELLS; LONG-TERM; ADULT; ABSENCE; IMPAIRS; PHOSPHORYLATION; IDENTIFICATION;
D O I：
10.1002/JLB.1HI0917-373R
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The switch from fetal to adult hematopoietic stem/progenitor cells (HSPCs) is associated with profound changes in several genetic programs. Although HSPC ageing corresponds to alterations in Wnt signaling, relatively little is known about the relative roles of different Wnt signaling pathways in HSPC ontogeny. We hypothesized that proliferating fetal HSPCs would be more dependent on canonical beta-catenin-dependent Wnt signaling when compared to quiescent adult bone marrow HSPCs. We have compared here Wnt signaling activities in murine fetal and adult HSPCs and demonstrate a shift from Wnt/beta-catenin-dependent signaling in fetal liver HSPCs to more predominantly noncanonical Wnt/polarity signaling in adult HSPCs. beta-Catenin was selectively required for fetal HSPC competitiveness shortly after transplant, and protected cells from oxidative stress. Our results emphasize the complexity of Wnt signaling dynamics in HSPC maintenance and function.
引用
收藏
页码：381 / 393
页数：13
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