Rapamycin in aging and disease: maximizing efficacy while minimizing side effects

被引：39

作者：

Johnson, Simon C. ^{[1
]}

Kaeberlein, Matt ^{[2
]}

机构：

[1] Albert Einstein Coll Med, Dept Genet, New York, NY USA

[2] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

ONCOTARGET | 2016年 / 7卷 / 29期

关键词：

mTOR; target of rapamycin; healthspan; mitochondria; mitochondria disease; MITOCHONDRIAL DISEASE; MTOR INHIBITION; LIFE-SPAN;

D O I：

10.18632/oncotarget.10381

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Experimental geroscience has identified rapamycin as a top candidate for promoting healthy aging and longevity in mammals. As multiple independent studies have successfully reproduced the lifespan and healthspan promoting effects of rapamycin, the focus has shifted to possible translational use. While a promising compound, clinical use of rapamycin is limited by concerns of side effects associated with the drug. Studies aimed at defining optimal dosage regimen, delivery route, and formulation will allow for benefits to be maximized while reducing side effects.

引用

页码：44876 / 44878

页数：3

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