The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses

被引：17
作者：
Barao, Isabel [1 ]
机构：
[1] Univ Nevada, Dept Microbiol & Immunol, Reno, NV 89557 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2013年 / 3卷
关键词：
NK; leukemia; 4-1BB; GITR; therapy;
D O I：
10.3389/fimmu.2012.00402
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interactions between several tumor necrosis factor (TNF)-TNF receptor (TNFR) superfamily members that are expressed by T cells and natural killer (NK) cells and various other cell types modulate immune responses. This review summarizes the current understanding of how the TNF ligand-TNFR interactions 4-1BBL with 4-1BB, and GITRL with glucocorticoid-induced TNFR-related (GITR) regulate NK cell mediated antitumor responses and discuss its therapeutic implications.
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页数：8
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