Soluble Factors of Amnion-Derived Cells in Treatment of Inflammatory and Fibrotic Pathologies

被引:69
作者
Silini, Antonietta [1 ]
Parolini, Ornella [1 ]
Huppertz, Berthold [2 ]
Lang, Ingrid [2 ]
机构
[1] Fdn Poliambulanza, Ctr Ric E Menni, Brescia, Italy
[2] Med Univ Graz, Inst Cell Biol Histol & Embryol, Graz, Austria
关键词
Amnion; fibrosis; inflammation; placenta; soluble factors; wound healing; MESENCHYMAL STEM-CELLS; TRANSFORMING-GROWTH-FACTOR; HUMAN TERM PLACENTA; UMBILICAL-CORD; MEMBRANE TRANSPLANTATION; HEPATIC-FIBROSIS; LIVER FIBROSIS; DIFFERENTIATION; SUPPRESSION; MECHANISMS;
D O I
10.2174/1574888X11308010003
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Inflammation is a complex defense mechanism characterized by leukocyte migration from the vasculature into damaged tissues and subsequent deposition of extracellular matrix resulting in tissue repair. The inflammatory process is generally categorized into an acute, rapid response, and a persistent but slowly evolving chronic condition, which may progress into inflammatory diseases. An excessive deposition of extracellular matrix leads to overgrowth, hardening, and/or scarring of tissues, defined as fibrosis. The amnion has been used as biomaterial in medicine for over 100 years and has been proven valuable for the treatment of different pathological conditions including wound healing. In light of recent reports, this article will review the effects of the amnion and its cellular components within the inflammatory-fibrotic scenario and the factors described so far that could be involved in these immunomodulatory actions. As proof of principles, we will also discuss pre-clinical and clinical applications of the amnion where advantage has been taken of its anti-inflammatory and anti-fibrotic properties. It is conceivable that the local host environment in which the amnion is placed may have a profound role in influencing the production and function of soluble factors and the shift towards different steps in triggering healing. The healing effect depends on time, dosage, and location of cytokine/growth factor production by the amnion, together with the influence of the host microenvironment. Indeed, determining the specific cascade of events that may define the role of the amnion in a given clinical situation remains a challenge.
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页码:6 / 14
页数:9
相关论文
共 102 条
[1]   Term amniotic membrane is a high throughput source for multipotent mesenchymal stem cells with the ability to differentiate into endothelial cells in vitro [J].
Alviano, Francesco ;
Fossati, Valentina ;
Marchionni, Cosetta ;
Arpinati, Mario ;
Bonsi, Laura ;
Franchina, Michele ;
Lanzoni, Giacomo ;
Cantoni, Silvia ;
Cavallini, Claudia ;
Bianchi, Francesca ;
Tazzari, Pier Luigi ;
Pasquinelli, Gianandrea ;
Foroni, Laura ;
Ventura, Carlo ;
Grossi, Alberto ;
Bagnara, Gian Paolo .
BMC DEVELOPMENTAL BIOLOGY, 2007, 7
[2]   Wharton's Jelly Mesenchymal Stem Cells as Candidates for Beta Cells Regeneration: Extending the Differentiative and Immunomodulatory Benefits of Adult Mesenchymal Stem Cells for the Treatment of Type 1 Diabetes [J].
Anzalone, Rita ;
Lo Iacono, Melania ;
Loria, Tiziana ;
Di Stefano, Antonino ;
Giannuzzi, Pantaleo ;
Farina, Felicia ;
La Rocca, Giampiero .
STEM CELL REVIEWS AND REPORTS, 2011, 7 (02) :342-363
[3]   New Emerging Potentials for Human Wharton's Jelly Mesenchymal Stem Cells: Immunological Features and Hepatocyte-Like Differentiative Capacity [J].
Anzalone, Rita ;
Lo Iacono, Melania ;
Corrao, Simona ;
Magno, Francesca ;
Loria, Tiziana ;
Cappello, Francesco ;
Zummo, Giovanni ;
Farina, Felicia ;
La Rocca, Giampiero .
STEM CELLS AND DEVELOPMENT, 2010, 19 (04) :423-438
[4]  
Apte RS, 1998, J IMMUNOL, V160, P5693
[5]   Clinical Application of a Hyperdry Amniotic Membrane on Surgical Defects of the Oral Mucosa [J].
Arai, Naoya ;
Tsuno, Hiroaki ;
Okabe, Motonori ;
Yoshida, Toshiko ;
Koike, Chika ;
Noguchi, Makoto ;
Nikaido, Toshio .
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2012, 70 (09) :2221-2228
[6]  
Baradaran-Rafii A., 2007, Journal of Ophthalmic Vision Research, P58
[7]   Amnion in the treatment of pediatric partial-thickness facial burns [J].
Branski, Ludwik K. ;
Herndon, David N. ;
Celis, Mario M. ;
Norbury, William B. ;
Masters, Oscar E. ;
Jeschke, Marc G. .
BURNS, 2008, 34 (03) :393-399
[8]   Conditioned medium from amniotic mesenchymal tissue cells reduces progression of bleomycin-induced lung fibrosis [J].
Cargnoni, Anna ;
Ressel, Lorenzo ;
Rossi, Daniele ;
Poli, Alessandro ;
Arienti, Davide ;
Lombardi, Guerino ;
Parolini, Ornella .
CYTOTHERAPY, 2012, 14 (02) :153-161
[9]   Transplantation of Allogeneic and Xenogeneic Placenta-Derived Cells Reduces Bleomycin-Induced Lung Fibrosis [J].
Cargnoni, Anna ;
Gibelli, Lucia ;
Tosini, Alessandra ;
Signoroni, Patrizia Bonassi ;
Nassuato, Claudia ;
Arienti, Davide ;
Lombardi, Guerino ;
Albertini, Alberto ;
Wengler, Georg S. ;
Parolini, Ornella .
CELL TRANSPLANTATION, 2009, 18 (04) :405-422
[10]  
Ching Yiu-Hei, 2011, Eplasty, V11, pe41