The spike protein of SARS-CoV - a target for vaccine and therapeutic development

被引：1195

作者：

Du, Lanying ^{[1
]}

He, Yuxian ^{[1
]}

Zhou, Yusen ^{[2
]}

Liu, Shuwen ^{[3
]}

Zheng, Bo-Jian ^{[4
]}

Jiang, Shibo ^{[1
]}

机构：

[1] New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10065 USA

[2] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

[3] So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

[4] Univ Hong Kong, Dept Microbiol, Pokfulam, Hong Kong, Peoples R China

来源：

NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ACUTE-RESPIRATORY-SYNDROME; RECEPTOR-BINDING DOMAIN; SYNDROME-ASSOCIATED CORONAVIRUS; HUMAN MONOCLONAL-ANTIBODY; SYNDROME (SARS)-ASSOCIATED CORONAVIRUS; ANGIOTENSIN-CONVERTING ENZYME-2; POTENT NEUTRALIZING ANTIBODIES; CELLULAR IMMUNE-RESPONSES; REPEAT-DERIVED PEPTIDES; AMINO-ACID SUBSTITUTION;

D O I：

10.1038/nrmicro2090

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike ( S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. In this Review, we highlight recent advances in the development of vaccines and therapeutics based on the S protein.

引用

页码：226 / 236

页数：11

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