The spike protein of SARS-CoV - a target for vaccine and therapeutic development

被引：1179
作者：
Du, Lanying [1 ]
He, Yuxian [1 ]
Zhou, Yusen [2 ]
Liu, Shuwen [3 ]
Zheng, Bo-Jian [4 ]
Jiang, Shibo [1 ]
机构：
[1] New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10065 USA
[2] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
[3] So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
[4] Univ Hong Kong, Dept Microbiol, Pokfulam, Hong Kong, Peoples R China
来源：
NATURE REVIEWS MICROBIOLOGY | 2009年 / 7卷 / 03期
基金：
美国国家卫生研究院;
关键词：
ACUTE-RESPIRATORY-SYNDROME; RECEPTOR-BINDING DOMAIN; SYNDROME-ASSOCIATED CORONAVIRUS; HUMAN MONOCLONAL-ANTIBODY; SYNDROME (SARS)-ASSOCIATED CORONAVIRUS; ANGIOTENSIN-CONVERTING ENZYME-2; POTENT NEUTRALIZING ANTIBODIES; CELLULAR IMMUNE-RESPONSES; REPEAT-DERIVED PEPTIDES; AMINO-ACID SUBSTITUTION;
D O I：
10.1038/nrmicro2090
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease caused by a novel coronavirus, SARS-coronavirus (SARS-CoV). The SARS-CoV spike ( S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. In this Review, we highlight recent advances in the development of vaccines and therapeutics based on the S protein.
引用
收藏
页码：226 / 236
页数：11
相关论文
共 143 条
  • [1] Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and S
    Akerstrom, Sara
    Mirazimi, Ali
    Tan, Yee-Joo
    [J]. ANTIVIRAL RESEARCH, 2007, 73 (03) : 219 - 227
  • [2] Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor
    Babcock, GJ
    Esshaki, DJ
    Thomas, WD
    Ambrosino, DM
    [J]. JOURNAL OF VIROLOGY, 2004, 78 (09) : 4552 - 4560
  • [3] Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice
    Bisht, H
    Roberts, A
    Vogel, L
    Bukreyev, A
    Collins, PL
    Murphy, BR
    Subbarao, K
    Moss, B
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) : 6641 - 6646
  • [4] Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E
    Bonavia, A
    Zelus, BD
    Wentworth, DE
    Talbot, PJ
    Holmes, KV
    [J]. JOURNAL OF VIROLOGY, 2003, 77 (04) : 2530 - 2538
  • [5] Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide
    Bosch, Berend Jan
    Bartelink, Willem
    Rottier, Peter J. M.
    [J]. JOURNAL OF VIROLOGY, 2008, 82 (17) : 8887 - 8890
  • [6] Severe acute respiratory syndrome coroavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides
    Bosch, BJ
    Martina, BEE
    van der Zee, R
    Lepault, J
    Haijema, BJ
    Versluis, C
    Heck, AJR
    de Groot, R
    Osterhaus, ADME
    Rottier, PJM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (22) : 8455 - 8460
  • [7] Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity
    Buchholz, UJ
    Bukreyev, A
    Yang, LJ
    Lamirande, EW
    Murphy, BR
    Subbarao, K
    Collins, PL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) : 9804 - 9809
  • [8] Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS
    Bukreyev, A
    Lamirande, EW
    Buchholz, UJ
    Vogel, LN
    Elkins, WR
    St Claire, M
    Murphy, BR
    Subbarao, K
    Collins, PL
    [J]. LANCET, 2004, 363 (9427) : 2122 - 2127
  • [9] HIV entry and its inhibition
    Chan, DC
    Kim, PS
    [J]. CELL, 1998, 93 (05) : 681 - 684
  • [10] A patient with asymptomatic severe acute respiratory syndrome (SARS) and antigenemia from the 2003-2004 community outbreak of SARS in Guangzhou, China
    Che, Xiao-yan
    Di, Biao
    Zhao, Guo-ping
    Wang, Ya-di
    Qiu, Li-wen
    Hao, Wei
    Wang, Ming
    Qin, Peng-zhe
    Liu, Yu-fei
    Chan, Kwok-hong
    Cheng, Vincent C. C.
    Yuen, Kwok-Yung
    [J]. CLINICAL INFECTIOUS DISEASES, 2006, 43 (01) : E1 - E5
12345678910