Lentinus edodes Polysaccharides Alleviate Acute Lung Injury by Inhibiting Oxidative Stress and Inflammation

被引：28

作者：

Zhang, Yiwen ^{[1
]}

Cui, Yanfei ^{[1
]}

Feng, Yanbo ^{[1
]}

Jiao, Fengping ^{[2
,3
]}

Jia, Le ^{[1
]}

机构：

[1] Shandong Agr Univ, Coll Life Sci, Tai An 271018, Shandong, Peoples R China

[2] Shandong First Med Univ, Sch Publ Hlth, Jinan 250117, Peoples R China

[3] Shandong Acad Med Sci, Jinan 250117, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 21期

关键词：

antioxidant activities; anti-inflammatory; acute lung injury; Lentinula edodes polysaccharides; pulmonary protection; NMR CHARACTERIZATION; MEDICINAL MUSHROOMS; GANODERMA-LUCIDUM; RECEPTOR; ANTIOXIDANT; PROTEIN; SARS; IL-6;

D O I：

10.3390/molecules27217328

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute lung injury (ALI) is a kind of lung disease with acute dyspnea, pulmonary inflammation, respiratory distress, and non-cardiogenic pulmonary edema, accompanied by the mid- and end-stage characteristics of COVID-19, clinically. It is imperative to find non-toxic natural substances on preventing ALI and its complications. The animal experiments demonstrated that Lentinus edodes polysaccharides (PLE) had a potential role in alleviating ALI by inhibiting oxidative stress and inflammation, which was manifested by reducing the levels of serum lung injury indicators (C3, hs-CRP, and GGT), reducing the levels of inflammatory factors (TNF-alpha, IL-1 beta, and IL-6), and increasing the activities of antioxidant enzymes (SOD and CAT) in the lung. Furthermore, PLE had the typical characteristics of pyran-type linked by beta-type glycosidic linkages. The conclusions indicated that PLE could be used as functional foods and natural drugs in preventing ALI.

引用

页数：13

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