The Adolescent and Young Adult with Cancer: State of the Art-- Acute Leukemias

被引：31

作者：

Gramatges, M. Monica ^{[1
]}

Rabin, Karen R. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Pediat Hematol Oncol, Texas Childrens Canc Ctr, Houston, TX 77030 USA

来源：

CURRENT ONCOLOGY REPORTS | 2013年 / 15卷 / 04期

关键词：

Acute lymphoblastic leukemia; Acute myeloid leukemia; Adolescent; Young adult; Treatment-related toxicity; Osteonecrosis; Pancreatitis; Thromboembolism; Hyperglycemia; Obesity; Adherence; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; CHILDRENS ONCOLOGY GROUP; ASPARAGINASE-ASSOCIATED PANCREATITIS; HIGH-DOSE METHOTREXATE; BODY-MASS INDEX; INDUCTION THERAPY; RISK-FACTORS; UNITED-STATES; OSTEONECROSIS;

D O I：

10.1007/s11912-013-0325-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite survival gains over the past several decades, adolescent and young adult (AYA) patients with both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) demonstrate a consistent survival disadvantage. The AYA population exhibits unique disease and host characteristics, and further study is needed to improve their outcomes. This review will highlight distinctive aspects of disease biology in this population, as well as salient treatment-related toxicities including osteonecrosis, pancreatitis, thromboembolism, hyperglycemia, and infections. The impact of obesity and differences in drug metabolism and chemotherapy resistance will also be discussed, as well as optimal treatment considerations for the AYA population.

引用

页码：317 / 324

页数：8

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