Toxicological evaluation of magnetic ionic liquids in human cell lines

被引：58

作者：

Frade, Raquel F. M. ^{[1
]}

Simeonov, Svilen ^{[1
]}

Rosatella, Andreia A. ^{[1
]}

Siopa, Filipa ^{[1
]}

Afonso, Carlos A. M. ^{[1
]}

机构：

[1] Univ Lisbon, iMed UL, Fac Farm, P-1649003 Lisbon, Portugal

来源：

CHEMOSPHERE | 2013年 / 92卷 / 01期

关键词：

Magnetic ionic liquids; Toxicity; Cell lines; Risk assessment; FUNCTIONALIZED SIDE-CHAINS; DIFFERENT HEAD GROUPS; ANTIMALARIAL ACTIVITY; TOXICITY; DESIGN; ANION; BIOTRANSFORMATIONS; CYTOTOXICITY; BIOCATALYSIS; COMPLEXES;

D O I：

10.1016/j.chemosphere.2013.02.047

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Magnetic ionic liquids (MILs) are new solvents with an interesting broad of applications however their toxicity is still an open issue. In this paper we report the toxicity of [C8MIM] and [Choline-C-n] based magnetic ionic liquids assessed in two human cell lines: normal skin fibroblasts (CRL-1502) and colorectal adenocarcinoma cells (CaCo-2), acquiring this last characteristics of human enterocytes after differentiation. The results showed that [CoCl4] and [MnCl4] are more prone to generate cytotoxicity. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：100 / 105

页数：6

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