How well do laboratories adhere to recommended guidelines for dyslipidaemia management in Europe? The CArdiac MARker Guideline Uptake in Europe (CAMARGUE) study

被引：12

作者：

De Wolf, Helene A. ^{[1
,2
]}

Langlois, Michel R. ^{[1
,2
]}

Suvisaari, Janne ^{[3
]}

Aakre, Kristin M. ^{[4
,5
]}

Baum, Hannsjorg ^{[6
]}

Collinson, Paul ^{[7
,8
,9
]}

Duff, Christopher J. ^{[10
,11
]}

Gruson, Damien ^{[12
,13
]}

Hammerer-Lercher, Angelika ^{[14
]}

Pulkki, Kari ^{[3
]}

Stankovic, Sanja ^{[15
]}

Stavljenic-Rukavina, Ana ^{[16
]}

Laitinen, Paivi ^{[3
]}

机构：

[1] AZ St Jan Brugge Oostende AV, Dept Lab Med, Brugge, Belgium

[2] Univ Ghent, Fac Med & Hlth Sci, Ghent, Belgium

[3] Helsinki Univ Hosp, Dept Clin Chem, HUSLAB, Helsinki, Finland

[4] Haukeland Hosp, Dept Med Biochem & Pharmacol, Bergen, Norway

[5] Univ Bergen, Dept Clin Sci, Bergen, Norway

[6] Reg Kliniken Holding RKH GmbH, Inst Lab Med, Mikrobiol & Blutdepot, Ludwigsburg, Germany

[7] St Georges Univ Hosp NHS Fdn Trust, Dept Clin Blood Sci, London, England

[8] St Georges Univ Hosp NHS Fdn Trust, Dept Cardiol, London, England

[9] St Georges Univ London, London, England

[10] Univ Hosp North Midlands NHS Trust, Dept Clin Biochem, Stoke On Trent, Staffs, England

[11] Keele Univ, Sch Primary Community & Social Care, Stoke On Trent, Staffs, England

[12] Clin Univ St Luc, Dept Clin Biochem, Brussels, Belgium

[13] Catholic Univ Louvain, Brussels, Belgium

[14] Cantonal Hosp Aarau AG, Inst Lab Med, Aarau, Switzerland

[15] Clin Ctr Serbia, Ctr Med Biochem, Belgrade, Serbia

[16] Libertas Int Univ, Zagreb, Croatia

来源：

CLINICA CHIMICA ACTA | 2020年 / 508卷

关键词：

Guidelines; Lipids; Pre-analytical; Analytical; Post-analytical; DENSITY-LIPOPROTEIN CHOLESTEROL; FAMILIAL HYPERCHOLESTEROLEMIA; LIPID PROFILE; RISK; DISEASE; HDL; EAS;

D O I：

10.1016/j.cca.2020.05.038

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The CArdiac MARker Guidelines Uptake in Europe Study (CAMARGUE) initiated by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) aims to survey the current use of evidence-based guidelines for dyslipidemia testing in Europe. Methods: In 2019 a web-based questionnaire was distributed via EFLM National Societies to clinical laboratories in Europe. Questions covered pre-analytics, analytical methods, measurement units, flagging of decision thresholds, and use of decision-enhancing comments. Results: Returns were obtained from 452 laboratories from 28 countries. Most laboratories always use nonfasting blood samples for lipid assays (66%). Lipid profiles are reported in mmol/L by 59% of the laboratories, mainly from 14 countries promoting the use of SI units. Important differences in flagging of decision thresholds were observed, with less than half of the laboratories applying the guideline-recommended LDL cholesterol threshold. Only 17% of the laboratories add an alert comment when familial hypercholesterolemia is suspected and 23% when risk of pancreatitis from hypertriglyceridemia is high. Conclusions: There are marked differences among laboratories in Europe in terms of pre-analytical, analytical, and post-analytical lipid management that could have an important clinical impact. This relates to different availability of assays or different laboratory practices on reporting and flagging of lipid profiles.

引用

页码：267 / 272

页数：6

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