Limb-bud and Heart Overexpression Inhibits the Proliferation and Migration of PC3M Cells

被引:13
作者
Liu, Qicai [1 ,2 ,3 ,4 ,5 ]
Li, Ermao [6 ,7 ]
Huang, Long [6 ]
Cheng, Minsheng [1 ,2 ,3 ,4 ,5 ]
Li, Li [1 ,2 ,3 ]
机构
[1] Southern Med Univ, Zhujiang Hosp, Guangdong Prov Biomed Engn Technol Res Ctr Cardio, Guangzhou 510280, Guangdong, Peoples R China
[2] Southern Med Univ, Zhujiang Hosp, Sino Japanese Cooperat Platform Translat Res Hear, Guangzhou 510280, Guangdong, Peoples R China
[3] Southern Med Univ, Zhujiang Hosp, Lab Heart Ctr, 253 Ind Ave Middle, Guangzhou 510280, Guangdong, Peoples R China
[4] Southern Med Univ, Zhujiang Hosp, Dept Cardiol, Guangzhou, Guangdong, Peoples R China
[5] Southern Med Univ, Zhujiang Hosp, Heart Ctr, Guangzhou, Guangdong, Peoples R China
[6] Sun Yat Sen Univ, Canc Ctr, Imaging Diag & Intervent Ctr, State Key Lab Oncol South China, 651 Dongfeng Rd East, Guangzhou 510660, Guangdong, Peoples R China
[7] Guangzhou Med Univ, Affiliated Hosp 1, Minimally Invas Surg Ctr, Dept Urol, Guangzhou 510120, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
LBH; Prostate cancer; Proliferation; Cell cycle; Migration; WNT SIGNALING PATHWAY; PROSTATE-CANCER; TUMOR-SUPPRESSOR; COFACTOR LBH; C-MYC; TRANSCRIPTION; CARCINOMA; CYCLIN; TARGET; MODEL;
D O I
10.7150/jca.21375
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The limb-bud and heart gene (LBH) was discovered in the early 21st century and is specifically expressed in the mouse embryonic limb and heart development. Increasing evidences have indicated that LBH not only plays an important role in embryo development, it is also closely correlated with the occurance and progression of many tumors. However, its function in prostate cancer (PCa) is still not well understood. Here, we explored the effects of LBH on the proliferation and migration of the PCa cell line PC3M. Methods: LBH expression in tissues and cell lines of PCa was detected by immunohistochemistry and Western blotting. Lentivirus was used to transduct the LBH gene into the PC3M cells. Stable LBH-overexpressing PC3M-LBH cells and PC3M-NC control cells were obtained via puromycin screening. Cell proliferation was examined using the 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Cell cycle distribution and apoptosis rate were investigated using flow cytometry. Cell migration was studied using the Transwell assay. Results: LBH expression level was down-regulated in 3 different PCa cell lines, especially in PC3M cells, compared with the normal prostate epithelial cells(RWPE-1). Cell lines of LBH-upregulated PC3M-LBH and PC3M-NC control were successfully constructed. Significantly increased LBH expression level and decreased cyclin D1 and cyclin E2 expression level was found in PC3M-LBH cells as compared to the PC3M-NC cells. The overexpression of LBH significantly inhibited PC3M cell proliferation in vitro and tumor growth in nude mice. LBH overexpression in PC3M cell, also induced cell cycle G0/G1 phase arrest and decreased the migration of PC3M cells. Conclusions: Our results reveal that LBH expression is down-regulated in the tissue and cell lines of PCa. LBH overexpression inhibits PC3M cell proliferation and tumor growth by inducing cell cycle arrest through down-regulating cyclin D1and cyclin E2 expression. LBH might be a therapeutic target and potential diagnostic marker in PCa.
引用
收藏
页码:424 / 432
页数:9
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