When membranes need an ESCRT: endosomal sorting and membrane remodelling in health and disease

被引：22

作者：

Alfred, Victor ^{[1
]}

Vaccari, Thomas ^{[1
]}

机构：

[1] IFOM FIRC Inst Mol Oncol, Milan, Italy

来源：

SWISS MEDICAL WEEKLY | 2016年 / 146卷

关键词：

ESCRT; endosomal sorting; MVB biogenesis; membrane remodelling; signal transduction; nuclear envelope; neurodegeneration; viral infection; cancer; TUMOR-SUPPRESSOR GENE; WIDE RNAI SCREEN; DOWN-REGULATION; MULTIVESICULAR BODIES; TRANSCRIPTION FACTOR; ALPHA-SYNUCLEIN; III COMPLEX; HD-PTP; TYROSINE PHOSPHORYLATION; FRONTOTEMPORAL DEMENTIA;

D O I：

10.4414/smw.2016.14347

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell. Deregulation of ESCRT activity is observed in neuro-degenerative diseases, virus infection and cancer. However, the mechanisms of pathogenesis involving ESCRTs have not yet fully come into focus. Here, we review the current knowledge of ESCRT function in health and disease and provide educated guesses for future research and focused therapeutic intervention.

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页数：14

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