Serum IL18 is associated with hemophagocytosis and poor survival in extranodal natural killer/T-cell lymphoma

被引：13

作者：

Lim, Sung Won ^{[1
]}

Ryu, Kyung Ju ^{[2
]}

Lee, Hansang ^{[1
]}

Ko, Young Hyeh ^{[3
]}

Kim, Won Seog ^{[1
]}

Kim, Seok Jin ^{[1
,2
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Hematol Oncol, 81 Irwon Ro, Seoul 06351, South Korea

[2] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Seoul, South Korea

[3] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul, South Korea

来源：

LEUKEMIA & LYMPHOMA | 2019年 / 60卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Interleukin-18; cytokine; extranodal NK; T cell lymphoma; hemophagocytosis; (NK)/T-CELL LYMPHOMA; PROGNOSTIC INDEX; INTERLEUKIN-18; GAMMA; EXPRESSION; RITUXIMAB; DIAGNOSIS; SMILE; GENE;

D O I：

10.1080/10428194.2018.1480772

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extranodal natural killer/T-cell lymphoma (ENKTL) is associated with Epstein-Barr virus (EBV) infection, a common cause of hemophagocytosis. As interleukin-18 (IL18) is related with hemophagocytosis, we measured serum IL18 and IL18-related cytokines of newly diagnosed patients with ENKTL (N = 114) to investigate the role as a biomarker for hemophagocytosis and determine the prognosis of ENKTL. The median value of serum IL18 was 20.5 pg/mL (1.23-2021.81 pg/mL). The high IL18 group (>= 20.5 pg/mL) was associated with stage III/IV, the presence of hemophagocytosis and poor treatment outcome. Serum IL18 showed significant positive correlations with TNF alpha, IFN gamma, and IP10. Overall survival was significantly different between the high and low IL18 groups (p < .001), and high serum IL18 was independently prognostic for survival in the multivariate analysis. In conclusion, serum IL18 levels may be associated with the hemophagocytosis and poor survival outcomes in patients with ENKTL.

引用

收藏

页码：317 / 325

页数：9

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