How telomerase reaches its end: Mechanism of telomerase regulation by the telomeric complex

被引：123

作者：

Bianchi, Alessandro ^{[1
,2
]}

Shore, David ^{[1
,2
]}

机构：

[1] Univ Geneva, Dept Mol Biol, CH-1211 Geneva, Switzerland

[2] Univ Geneva, NCCR Frontiers Genet Program, CH-1211 Geneva, Switzerland

来源：

MOLECULAR CELL | 2008年 / 31卷 / 02期

关键词：

D O I：

10.1016/j.molcel.2008.06.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at individual chromosome ends by the telomeric protein/DNA complex in a manner dependent on telomere repeat-array length. A dynamic interplay between telomerase-inhibiting factors bound at duplex DNA repeats and telomerasepromoting ones bound at single-stranded terminal DNA overhangs appears to modulate telomerase activity and to be directly related to the transient deprotection of telomeres. We discuss recent advances on the mechanism of telomerase regulation at chromosome ends in both yeast and mammalian systems.

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收藏

页码：153 / 165

页数：13

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