Central-line associated bloodstream infections in a tertiary care children's University hospital: a prospective study

被引：24

作者：

Venturini, Elisabetta ^{[1
]}

Montagnani, Carlotta ^{[1
]}

Benni, Alessandra ^{[1
]}

Becciani, Sabrina ^{[1
]}

Biermann, Klaus Peter ^{[2
]}

De Masi, Salvatore ^{[2
]}

Chiappini, Elena ^{[1
]}

de Martino, Maurizio ^{[1
]}

Galli, Luisa ^{[1
,2
,3
]}

机构：

[1] Univ Florence, Meyer Childrens Univ Hosp, Dept Hlth Sci, Florence, Italy

[2] Meyer Childrens Hosp, Healthcare Associated Infect Control Comm, Florence, Italy

[3] Meyer Childrens Univ Hosp, Dept Pediat Med, Pediatr Infect Dis Div, Viale Pieraccini 24, I-50139 Florence, Italy

来源：

BMC INFECTIOUS DISEASES | 2016年 / 16卷

关键词：

CLABSI; Children; Central-line; Infection; CENTRAL VENOUS CATHETERS; CARBAPENEM-RESISTANT ENTEROBACTERIACEAE; COMPLICATIONS; INFANTS; COSTS; US;

D O I：

10.1186/s12879-016-2061-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: The central-line associated bloodstream infections (CLABSI) are the most common healthcare-associated infections in childhood. Despite the international data available on healthcare-associated infections in selected groups of patients, there is a lack of large and good quality studies. The present survey is the first prospective study monitoring for 6 months the occurrence of central-line associated bloodstream infections in all departments of an Italian tertiary care children's university hospital. Methods: The study involved all children aged less than 18 years admitted to Meyer Children's University Hospital, Florence, Italy who had a central line access between the October 15th, 2014 and the April 14th, 2015. CLABSI were defined according to the Center for Disease Control and Prevention criteria. CLABSI incidence rates with 95% confidence limits were calculated and stratified for the study variables. For each factor the relative risk and 95% confidence intervals were evaluated. Statistical analysis was performed using the statistical software SPSS for Windows, version 22.0 (SPSS Inc., Chicago, IL), p < 0.05 was considered statistically significant. Results: CLABSI rate was 3.73/1000 (95% CI: 2.54-5.28) central line-days. A higher CLABSI incidence was seen with female gender (p = 0.045) and underlying medical conditions (excepting prematurity, surgical diseases and malignancy) (p = 0.06). In our study 5 infections, were caused by extended-spectrum beta-lactamase producing organisms and in one case by carbapenem-resistant Klebsiella pneumoniae. Conclusions: Our study confirms the spreading of multi-resistant pathogens as causes of healthcare-associated infections in children. An increased incidence rate of CLABSI in our study was related to underlying medical conditions. Pediatric studies focusing on healthcare infections in this type of patients should be done in order to deepen our understanding on associated risk factors and possible intervention areas.

引用

页数：7

共 26 条

[1] Central Line-Associated Bloodstream Infection in Hospitalized Children with Peripherally Inserted Central Venous Catheters: Extending Risk Analyses Outside the Intensive Care Unit [J].