Nonacetaminophen Drug-Induced Acute Liver Failure

Acute liver failure of all causes is diagnosed in between 2000 and 2500 patients annually in the United States. Drug-induced acute liver failure is the leading cause of acute liver failure, accounting for more than 50% of cases. Nonacetaminophen drug injury represents 11 % of all cases in the latest registry from the US Acute Liver Failure Study Group. Although acute liver failure is rare, it is clinically dramatic when it occurs and requires a multidisciplinary approach to management. In contrast with acetaminophen induced acute liver failure, non acetaminophen-induced acute liver failure has a more ominous prognosis with a lower liver transplant-free survival.