Nonacetaminophen Drug-Induced Acute Liver Failure

被引：9

作者：

Thomas, Arul M. ^{[1
]}

Lewis, James H. ^{[2
]}

机构：

[1] MedStar Georgetown Univ Hosp, MedStar Georgetown Transplant Inst, 3800 Reservoir Rd NW, Washington, DC 20007 USA

[2] MedStar Georgetown Univ Hosp, Div Gastroenterol, 3800 Reservoir Rd NW,Room M2408, Washington, DC 20007 USA

来源：

CLINICS IN LIVER DISEASE | 2018年 / 22卷 / 02期

关键词：

Drug-induced liver injury; Acute liver failure; Nonacetaminophen drug-induced liver injury;

D O I：

10.1016/j.cld.2018.01.006

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Acute liver failure of all causes is diagnosed in between 2000 and 2500 patients annually in the United States. Drug-induced acute liver failure is the leading cause of acute liver failure, accounting for more than 50% of cases. Nonacetaminophen drug injury represents 11 % of all cases in the latest registry from the US Acute Liver Failure Study Group. Although acute liver failure is rare, it is clinically dramatic when it occurs and requires a multidisciplinary approach to management. In contrast with acetaminophen induced acute liver failure, non acetaminophen-induced acute liver failure has a more ominous prognosis with a lower liver transplant-free survival.

引用

页码：301 / 324

页数：24

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