Endothelial dysfunction over the course of coronary artery disease

被引：292

作者：

Gutierrez, Enrique ^{[1
]}

Flammer, Andreas J. ^{[2
]}

Lerman, Lilach O. ^{[3
]}

Elizaga, Jaime ^{[1
]}

Lerman, Amir ^{[4
]}

Fernandez-Aviles, Francisco ^{[1
]}

机构：

[1] Univ Gregorio Maranon, Gen Hosp, Inst Invest Sanitaria, Serv Cardiol, Madrid, Spain

[2] Univ Zurich Hosp, Ctr Cardiovasc, CH-8091 Zurich, Switzerland

[3] Mayo Clin, Dept Nephrol & Hypertens, Rochester, MN USA

[4] Mayo Clin, Depte Cardiol, Rochester, MN USA

来源：

EUROPEAN HEART JOURNAL | 2013年 / 34卷 / 41期

基金：

美国国家卫生研究院;

关键词：

Endothelial dysfunction; Coronary heart disease; Heart failure; Heart transplant; Acetylcholine; FLOW-MEDIATED DILATION; CARDIAC RESYNCHRONIZATION THERAPY; CHRONIC HEART-FAILURE; CARDIOVASCULAR RISK-FACTORS; TYPE-2; DIABETIC-PATIENTS; SIROLIMUS-ELUTING STENT; DEPENDENT VASODILATION; NITRIC-OXIDE; PROGNOSTIC VALUE; VASCULAR FUNCTION;

D O I：

10.1093/eurheartj/eht351

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The vascular endothelium regulates blood flow in response to physiological needs. Endothelial dysfunction is closely related to atherosclerosis and its risk factors, and it constitutes an intermediate step on the progression to adverse events throughout the natural history of coronary artery disease (CAD), often affecting clinical outcomes. Understanding the relation of endothelial function with CAD provides an important pathophysiological insight, which can be useful both in clinical and research management. In this review, we summarize the current knowledge on endothelial dysfunction and its prognostic influence throughout the natural history of CAD, from early atherosclerosis to post-transplant management.

引用

页码：3175 / U12

页数：10

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