Synthesis of novel peptides through Ugi-ligation and their anti-cancer activities

被引：8

作者：

Tahoori, Fatemeh ^{[1
]}

Sheikhnejad, Reza ^{[2
]}

Balalaie, Saeed ^{[1
]}

Sadjadi, Mahnaz ^{[2
]}

机构：

[1] KN Toosi Univ Technol, Peptide Chem Res Ctr, Tehran, Iran

[2] Tofigh Daru Res & Engn Co, Tehran, Iran

来源：

AMINO ACIDS | 2013年 / 45卷 / 04期

关键词：

Ugi-ligation; Ligation of peptides; Anti-cancer activity; Pseudopeptides; NATIVE CHEMICAL LIGATION; EFFICIENT; PROTEINS; IDENTIFICATION; ANALOGS; DNA;

D O I：

10.1007/s00726-013-1554-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proline-rich heptapeptide was synthesized and its structure was modified through Ugi-ligation. The desired pseudopeptides were separated as diastereomers and their anti-cancer activities were investigated. Their in vitro anti-cancer activities were investigated by treating HL60 (leukemia cancer cells), MCF7 (breast cancer cells) and A549 (lung cancer cells) cells with appropriate amounts of synthesized peptides. Our in vitro studies suggest that compounds 11a-b, 11i-j, and 11e had little or no effect on cancer cells viabilities.

引用

收藏

页码：975 / 981

页数：7

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