Cyanation of indoles with benzyl cyanide as the cyanide anion surrogate

被引：52
作者：
Zhang, Lianpeng [1 ]
Wen, Qiaodong [1 ]
Jin, Jisong [1 ]
Wang, Chen [1 ]
Lu, Ping [1 ]
Wang, Yanguang [1 ]
机构：
[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Peoples R China
来源：
TETRAHEDRON | 2013年 / 69卷 / 21期
关键词：
Copper catalysis; Cyanation; Benzyl cyanide; 3-Cyanoindoles; PALLADIUM-CATALYZED CYANATION; ARYL HALIDE; DERIVATIVES; NITRILES; N; N-DIMETHYLFORMAMIDE; TRANSFORMATIONS; ACTIVATION; ANALOGS; KETONES; MILD;
D O I：
10.1016/j.tet.2013.03.089
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-mediated direct cyanation of indoles with benzyl cyanide as the cyanide anion surrogate has been achieved. The cascade reaction furnished 3-cyanoindoles under mild reaction conditions in good to excellent yields with various functional groups tolerance. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4236 / 4240
页数：5
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