Radiation therapy and immunotherapy: what is the optimal timing or sequencing?

被引:55
作者
Aliru, Maureen L. [1 ,3 ]
Schoenhals, Jonathan E. [1 ]
Venkatesulu, Bhanu P. [1 ]
Anderson, Clark C. [4 ,5 ]
Barsoumian, Hampartsoum B. [1 ]
Younes, Ahmed I. [1 ]
Mahadevan, Lakshmi S. K. [1 ]
Soeung, Melinda [6 ]
Aziz, Kathryn E. [1 ]
Welsh, James W. [1 ,2 ]
Krishnan, Sunil [1 ,2 ,3 ]
机构
[1] Univ Texas MD Anderson Canc Ctr UTHlth, Grad Sch Biomed Sci, Dept Expt Radiat Oncol, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr UTHlth, Grad Sch Biomed Sci, Med Phys Grad Program, Houston, TX 77030 USA
[4] Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA
[5] Ohio State Univ, Dept Mol & Cellular Biol, Columbus, OH 43210 USA
[6] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77030 USA
关键词
adoptive cell therapy; cancer immunotherapy; cancer vaccines; combination therapy; CTLA4; cytokines; immune checkpoint inhibitors; PD1; PDL1; radiation; sequence; timing; MELANOMA BRAIN METASTASES; IMMATURE DENDRITIC CELLS; TUMOR-NECROSIS-FACTOR; BREAST-CANCER; T-CELLS; ANTITUMOR IMMUNITY; STEREOTACTIC RADIOSURGERY; PROSTATE-CANCER; GENE-THERAPY; LUNG-CANCER;
D O I
10.2217/imt-2017-0082
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Radiotherapy is a component of the standard of care for many patients with locally advanced nonmetastatic tumors and increasingly those with oligometastatic tumors. Despite encouraging advances in local control and progression-free and overall survival outcomes, continued manifestation of tumor progression or recurrence leaves room for improvement in therapeutic efficacy. Novel combinations of radiation with immunotherapy have shown promise in improving outcomes and reducing recurrences by overcoming tumor immune tolerance and evasion mechanisms via boosting the immune system's ability to recognize and eradicate tumor cells. In this review, we discuss preclinical and early clinical evidence that radiotherapy and immunotherapy can improve treatment outcomes for locally advanced and metastatic tumors, elucidate underlying molecular mechanisms and address strategies to optimize timing and sequencing of combination therapy for maximal synergy.
引用
收藏
页码:299 / 316
页数:18
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