In vivo behavior of carboxymethylcellulose based microgels containing 67Cu

被引：5
|
作者：
Orlova, Marina A. [1 ,2 ]
V. Spiridonov, Vasiliy [1 ]
Badun, Gennadii A. [1 ]
Trofimova, Tatiana P. [1 ]
Orlov, Alexey P.
Zolotova, Alena S. [1 ]
Priselkova, Anna B. [3 ]
Aleshin, Gleb Yu. [1 ]
Chernysheva, Maria G. [1 ]
Yaroslavov, Alexander A. [1 ]
Kalmykov, Stepan N. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia
[2] NI Pirogov Russian Natl Res Med Univ, Moscow 117997, Russia
[3] Moscow MV Lomonosov State Univ, DV Skobeltsyn Inst Nucl Phys, Moscow 119991, Russia
来源：
MENDELEEV COMMUNICATIONS | 2022年 / 32卷 / 05期
关键词：
carboxymethyl cellulose; microgel; 67Cu; tritium; mouse model; organ distribution; radiation stability; COPPER; RADIONUCLIDES; COMPLEXES;
D O I：
10.1016/j.mencom.2022.09.030
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Using a mouse model, an organ distribution for microgels of carboxymethyl cellulose cross-linked with 67Cu2+ ions was investigated and compared with the distribution of free 67Cu2+ ions from 67CuCl2. The clearance of the microgels through both liver and kidneys was demonstrated. An additional examination of distribution for [3H]CMC microparticles and [3H]CMC-Cu microgels revealed no copper release from the microgels in vivo.
引用
收藏
页码：658 / 660
页数：3
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