The Preventive and Therapeutic Effects of Intravenous Human Adipose-Derived Stem Cells in Alzheimer's Disease Mice

被引：108
作者：
Kim, Saeromi [1 ]
Chang, Keun-A [1 ,4 ]
Kim, Jeong A. [1 ]
Park, Hyeong-Geun [2 ]
Ra, Jeong Chan [2 ]
Kim, Hye-Sun [1 ]
Suh, Yoo-Hun [1 ,3 ]
机构：
[1] Seoul Natl Univ, Coll Med, Neurosci Res Inst, MRC,Dept Pharmacol, Seoul, South Korea
[2] RNL Bio Co Ltd, Stem Cell Res Ctr, Seoul, South Korea
[3] Korea Brain Res Inst, Taegu, South Korea
[4] Gachon Univ Med & Sci, Dept Pharmacol, Inchon, South Korea
来源：
PLOS ONE | 2012年 / 7卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
STROMAL CELLS; NEURONAL DIFFERENTIATION; NEUROTROPHIC FACTORS; TRANSGENIC MODEL; AMYLOID-PROTEIN; NERVOUS-SYSTEM; GROWTH-FACTOR; MOUSE MODEL; IN-VITRO; TRANSPLANTATION;
D O I：
10.1371/journal.pone.0045757
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Alzheimer's disease (AD) is characterized by the accumulation of amyloid plaques and neurofibrillary tangles accompanied by cognitive dysfunction. The aim of the present study was to elucidate preventive and therapeutic potential of stem cells for AD. Among stem cells, autologous human adipose-derived stem cells (hASCs) elicit no immune rejection responses, tumorigenesis, or ethical problems. We found that intravenously transplanted hASCs passed through the BBB and migrated into the brain. The learning, memory and pathology in an AD mouse model (Tg2576) mice greatly improved for at least 4 months after intravenous injection of hASC. The number of amyloid plaques and A beta levels decreased significantly in the brains of hASC-injected Tg mice compared to those of Tg-sham mice. Here, we first report that intravenously or intracerebrally transplanted hASCs significantly rescues memory deficit and neuropathology, in the brains of Tg mice by upregulating IL-10 and VEGF and be a possible use for the prevention and treatment of AD.
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页数：17
相关论文
共 41 条
[1]  
Alzheimer's Association, 2010, Alzheimers Dement, V6, P158, DOI 10.1016/j.jalz.2010.01.009
[2]   Neuronal Differentiation Potential of Human Adipose-Derived Mesenchymal Stem Cells [J].
Anghileri, Elena ;
Marconi, Silvia ;
Pignatelli, Angela ;
Cifelli, Pierangelo ;
Galie, Mirco ;
Sbarbati, Andrea ;
Krampera, Mauro ;
Belluzzi, Ottorino ;
Bonetti, Bruno .
STEM CELLS AND DEVELOPMENT, 2008, 17 (05) :909-916
[3]   Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats [J].
Bao, Xinjie ;
Wei, Junji ;
Feng, Ming ;
Lu, Shan ;
Li, Guilin ;
Dou, Wanchen ;
Ma, Wenbin ;
Ma, Sihai ;
An, Yihua ;
Qin, Chuan ;
Zhao, Robert Chunhua ;
Wang, Renzhi .
BRAIN RESEARCH, 2011, 1367 :103-113
[4]   Locally Delivered Growth Factor Enhances the Angiogenic Efficacy of Adipose-Derived Stromal Cells Transplanted to Ischemic Limbs [J].
Bhang, Suk Ho ;
Cho, Seung-Woo ;
Lim, Jae Min ;
Kang, Jin Muk ;
Lee, Tae-Jin ;
Yang, Hee Seok ;
Song, Young Soo ;
Park, Moon Hyang ;
Kim, Hyo-Soo ;
Yoo, Kyung-Jong ;
Jang, Yangsoo ;
Langer, Robert ;
Anderson, Daniel G. ;
Kim, Byung-Soo .
STEM CELLS, 2009, 27 (08) :1976-1986
[5]   Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease [J].
Blurton-Jones, Mathew ;
Kitazawa, Masashi ;
Martinez-Coria, Hilda ;
Castello, Nicholas A. ;
Mueller, Franz-Josef ;
Loring, Jeanne F. ;
Yamasaki, Tritia R. ;
Poon, Wayne W. ;
Green, Kim N. ;
LaFerla, Frank M. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (32) :13594-13599
[6]   Immune Influence on Adult Neural Stem Cell Regulation and Function [J].
Carpentier, Pamela A. ;
Palmer, Theo D. .
NEURON, 2009, 64 (01) :79-92
[7]   THE RAT-BRAIN POSTSYNAPTIC DENSITY FRACTION CONTAINS A HOMOLOG OF THE DROSOPHILA DISKS-LARGE TUMOR SUPPRESSOR PROTEIN [J].
CHO, KO ;
HUNT, CA ;
KENNEDY, MB .
NEURON, 1992, 9 (05) :929-942
[8]   Natural oligomers of the amyloid-protein specifically disrupt cognitive function [J].
Cleary, JP ;
Walsh, DM ;
Hofmeister, JJ ;
Shankar, GM ;
Kuskowski, MA ;
Selkoe, DJ ;
Ashe, KH .
NATURE NEUROSCIENCE, 2005, 8 (01) :79-84
[9]   Role and Therapeutic Potential of VEGF in the Nervous System [J].
De Almodovar, Carmen Ruiz ;
Lambrechts, Diether ;
Mazzone, Massimiliano ;
Carmeliet, Peter .
PHYSIOLOGICAL REVIEWS, 2009, 89 (02) :607-648
[10]   Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells [J].
Dezawa, M ;
Takahashi, I ;
Esaki, M ;
Takano, M ;
Sawada, H .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 14 (11) :1771-1776
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