Evolutionary Trajectories of IDHWT Glioblastomas Reveal a Common Path of Early Tumorigenesis Instigated Years ahead of Initial Diagnosis

被引：179

作者：

Koerber, Verena ^{[1
,2
]}

Yang, Jing ^{[3
,4
]}

Barah, Pankaj ^{[3
]}

Wu, Yonghe ^{[5
,7
]}

Stichel, Damian ^{[6
]}

Gu, Zuguang ^{[3
,7
]}

Fletcher, Michael Nai Chung ^{[5
]}

Jones, David ^{[8
]}

Hentschel, Bettina ^{[9
]}

Lamszus, Katrin ^{[10
]}

Tonn, Joerg Christian ^{[11
,12
]}

Schackert, Gabriele ^{[13
]}

Sabel, Michael ^{[14
]}

Felsberg, Joerg ^{[15
,16
]}

Zacher, Angela ^{[15
,16
]}

Kaulich, Kerstin ^{[15
,16
]}

Huebschmann, Daniel ^{[3
]}

Herold-Mende, Christel ^{[17
]}

von Deimling, Andreas ^{[6
]}

Weller, Michael ^{[18
]}

Radlwimmer, Bernhard ^{[5
]}

Schlesner, Matthias ^{[4
]}

Reifenberger, Guido ^{[1
,4
]}

Hoefer, Thomas ^{[1
,2
]}

Lichter, Peter ^{[5
,7
]}

机构：

[1] German Canc Res Ctr, Div Theoret Syst Biol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Bioquant Ctr, Neuenheimer Feld 267, D-69120 Heidelberg, Germany

[3] German Canc Res Ctr, Div Theoret Bioinformat, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[4] German Canc Res Ctr, Bioinformat & Omics Data Analyt, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[5] German Canc Res Ctr, German Canc Res Consortium DKTK, Div Mol Genet, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[6] German Canc Res Ctr, Clin Cooperat Unit Neuropathol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[7] German Canc Res Ctr, Heidelberg Ctr Personalized Oncol, DKFZ HIPO, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[8] German Canc Res Ctr, Pediat Glioma Res, Neuenheimer Feld 280, D-69120 Heidelberg, Germany

[9] Univ Leipzig, Inst Med Informat Stat & Epidemiol, Hartelstr 16-18, D-04107 Leipzig, Germany

[10] Univ Med Ctr Hamburg Eppendorf, Dept Neurosurg, Neues Klinikum O10,Martinistr 52, D-20246 Hamburg, Germany

[11] Ludwig Maximilians Univ Munchen, Dept Neurosurg, Partner Site Munich,Marchioninistr 15, D-81377 Munich, Germany

[12] German Canc Consortium DKTK, Partner Site Munich,Marchioninistr 15, D-81377 Munich, Germany

[13] Tech Univ Dresden, Dept Neurosurg, Fetscherstr 74, D-01307 Dresden, Germany

[14] Heinrich Heine Univ Dusseldorf, Dept Neurosurg, Moorenstr 5, D-40255 Dusseldorf, Germany

[15] Heinrich Heine Univ Dusseldorf, Inst Neuropathol, Partner Site Essen Dusseldorf,Moorenstr 5, D-40255 Dusseldorf, Germany

[16] German Canc Consortium DKTK, Partner Site Essen Dusseldorf,Moorenstr 5, D-40255 Dusseldorf, Germany

[17] Heidelberg Univ Hosp, Dept Neurosurg, Neuenheimer Feld 400, D-69120 Heidelberg, Germany

[18] Univ Hosp Zurich, Dept Neurol, Frauenklinikstr 26, CH-8091 Zurich, Switzerland

来源：

CANCER CELL | 2019年 / 35卷 / 04期

关键词：

CENTRAL-NERVOUS-SYSTEM; INTRATUMORAL HETEROGENEITY; CLONAL EVOLUTION; TUMOR EVOLUTION; MUTATIONS; GLIOMA; PROMOTER; DATABASE; BRAIN; COMBINATION;

D O I：

10.1016/j.ccell.2019.02.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly regrowing tumor. We inferred the evolutionary trajectories of matched pairs of primary and relapsed tumors based on deep whole-genome-sequencing data. This analysis suggests both a distant origin of de novo glioblastoma, up to 7 years before diagnosis, and a common path of early tumorigenesis, with one or more of chromosome 7 gain, 9p loss, or 10 loss, at tumor initiation. TERT promoter mutations often occurred later as a prerequisite for rapid growth. In contrast to this common early path, relapsed tumors acquired no stereotypical pattern of mutations and typically regrew from oligoclonal origins, suggesting sparse selective pressure by therapeutic measures.

引用

页码：692 / +

页数：25

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