POTENTIAL FOR PALIVIZUMAB INTERFERENCE WITH COMMERCIALLY AVAILABLE ANTIBODY-ANTIGEN BASED RESPIRATORY SYNCYTIAL VIRUS DIAGNOSTIC ASSAYS

被引：6

作者：

Deming, Damon J. ^{[1
]}

Patel, Nita ^{[2
]}

McCarthy, Michael P. ^{[2
]}

Mishra, Lalji ^{[1
]}

Shapiro, Alan M. ^{[1
]}

Suzich, JoAnn A. ^{[2
]}

机构：

[1] US FDA, Ctr Drug Evaluat & Res, Off New Drugs, Off Antimicrobial Prod,Div Antiviral Prod, Silver Spring, MD 20993 USA

[2] MedImmune LLC, Gaithersburg, MD USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2013年 / 32卷 / 10期

关键词：

assay interference; palivizumab; respiratory syncytial virus; MONOCLONAL-ANTIBODY; INFECTIONS; INFANTS;

D O I：

10.1097/INF.0b013e31829561dd

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Palivizumab is a monoclonal antibody indicated for the prevention of serious lower respiratory tract disease caused by respiratory syncytial virus infection in infants. The potential for palivizumab to interfere with commercially available respiratory syncytial virus diagnostic tests was demonstrated. Negative test results in palivizumab-treated subjects should be interpreted with caution and confirmed by a nucleic acid amplification-based assay.

引用

页码：1144 / 1146

页数：3

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