Exploration of Plasma Lipids in Mild Cognitive Impairment due to Alzheimer's Disease

被引：9

作者：

Bergland, Anne Katrine ^{[1
,2
]}

Proitsi, Petroula ^{[3
]}

Kirsebom, Bjorn-Eivind ^{[4
,5
]}

Soennesyn, Hogne ^{[1
]}

Hye, Abdul ^{[3
]}

Larsen, Alf Inge ^{[2
,6
]}

Xu, Jin ^{[3
,7
]}

Legido-Quigley, Cristina ^{[7
,8
]}

Rajendran, Lawrence ^{[9
]}

Fladby, Tormod ^{[10
,11
]}

Aarsland, Dag ^{[1
,9
]}

机构：

[1] Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway

[2] Univ Bergen, Dept Clin Sci, Bergen, Norway

[3] Kings Coll London, Inst Psychiat Psychol & Neurosci, Maurice Wohl Clin Neurosci, London, England

[4] Univ Hosp North Norway, Dept Neurol, Tromso, Norway

[5] Arctic Univ Norway, Fac Hlth Sci, Dept Psychol, UiT, Tromso, Norway

[6] Stavanger Univ Hosp, Dept Cardiol, Stavanger, Norway

[7] Kings Coll London, Inst Pharmaceut Sci, London, England

[8] Steno Diabet Ctr, Syst Med, Copenhagen, Denmark

[9] Kings Coll London, UK Dementia Res Inst, Inst Psychiat Psychol & Neurosci, London, England

[10] Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway

[11] Univ Oslo, Inst Clin Med, Campus Ahus, Oslo, Norway

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2020年 / 77卷 / 03期

关键词：

Alzheimer's disease; lipid; mild cognitive impairment; sphingomyelin; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; RECOMMENDATIONS;

D O I：

10.3233/JAD-200441

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Lipids have important structural roles in cell membranes and changes to these membrane lipids may influence beta- and gamma-secretase activities and thus contribute to Alzheimer's disease (AD) pathology. Objective: To explore baseline plasma lipid profiling in participants with mild cognitive impairment (MCI) with and without AD pathology. Methods: We identified 261 plasma lipids using reversed-phase liquid chromatography/mass spectrometry in cerebrospinal fluid amyloid positive (A beta+) or negative (A beta-) participants with MCI as compared to controls. Additionally, we analyzed the potential associations of plasma lipid profiles with performance on neuropsychological tests at baseline and after two years. Results: Sphingomyelin (SM) concentrations, particularly, SM(d43:2), were lower in MCI A beta+ individuals compared to controls. Further, SM(d43:2) was also nominally reduced in MCI A beta+ individuals compared to MCI A beta-. No plasma lipids were associated with performance on primary neuropsychological tests at baseline or between the two time points after correction for multiple testing. Conclusion: Reduced plasma concentrations of SM were associated with AD.

引用

页码：1117 / 1127

页数：11

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