Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma

被引：75

作者：

De Veirman, Kim ^{[1
]}

Rao, Luigia ^{[1
,2
]}

De Bruyne, Elke ^{[1
]}

Menu, Eline ^{[1
]}

Van Valckenborgh, Els ^{[1
]}

Van Riet, Ivan ^{[1
,3
]}

Frassanito, Maria Antonia ^{[4
]}

Di Marzo, Lucia ^{[2
]}

Vacca, Angelo ^{[2
]}

Vanderkerken, Karin ^{[1
]}

机构：

[1] VUB, Myeloma Ctr Brussels, Dept Hematol & Immunol, B-1090 Brussels, Belgium

[2] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Sect Internal Med, I-70124 Bari, Italy

[3] UZ Brussel, Stem Cell Lab, Div Clin Hematol, B-1090 Brussels, Belgium

[4] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Sect Gen Pathol, I-70124 Bari, Italy

来源：

CANCERS | 2014年 / 6卷 / 03期

关键词：

multiple myeloma; hypoxia; cancer associated fibroblasts;

D O I：

10.3390/cancers6031363

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer associated fibroblasts (CAFs) comprise a heterogeneous population that resides within the tumor microenvironment. They actively participate in tumor growth and metastasis by production of cytokines and chemokines, and the release of pro-inflammatory and pro-angiogenic factors, creating a more supportive microenvironment. The aim of the current review is to summarize the origin and characteristics of CAFs, and to describe the role of CAFs in tumor progression and metastasis. Furthermore, we focus on the presence of CAFs in hypoxic conditions in relation to multiple myeloma disease.

引用

页码：1363 / 1381

页数：19

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