Cu Single Atom Nanozyme Based High-Efficiency Mild Photothermal Therapy through Cellular Metabolic Regulation

被引：96

作者：

Chang, Mengyu ^{[1
,2
]}

Hou, Zhiyao ^{[3
,4
]}

Wang, Man ^{[1
,5
]}

Wen, Ding ^{[1
]}

Li, Chunxia ^{[5
]}

Liu, Yuhui ^{[6
]}

Zhao, Yanli ^{[2
]}

Lin, Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Rare Earth Resource Utilizat, Changchun 130022, Peoples R China

[2] Nanyang Technol Univ, Sch Chem Chem Engn & Biotechnol, 21 Nanyang Link, Singapore 637371, Singapore

[3] Guangzhou Med Univ, Sch Basic Med Sci, Guangzhou Municipal & Guangdong Prov Key Lab Prot, Guangzhou 511436, Peoples R China

[4] Guangzhou Med Univ, Qingyuan Peoples Hosp, Affiliated Hosp 6, Qingyuan 511518, Peoples R China

[5] Shandong Univ, Inst Mol Sci & Engn, Qingdao 266237, Peoples R China

[6] East China Univ Technol, State Key Lab Nucl Resources & Environm, Nanchang 330013, Jiangxi, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2022年 / 61卷 / 50期

基金：

中国国家自然科学基金;

关键词：

Heat Shock Proteins; Mild Photothermal Therapy; Reactive Oxygen Species; Single Atom Nanozymes; Sodium-Dependent Glucose Transporter; ATP;

D O I：

10.1002/anie.202209245

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Upregulation of heat shock proteins (HSPs) drastically compromises the treatment effect of mild photothermal therapy (PTT). Herein, we designed a polyporous Cu single atom nanozyme (Cu SAzyme) loaded with licogliflozin (LIK066) for HSP-silencing induced mild PTT. On one hand, LIK066 inhibits glucose uptake by shutting sodium-dependent glucose transporter (SGLT) "valve", effectively blocking the energy source for adenosine triphosphate (ATP) generation. Without sufficient energy, cancer cells cannot synthesize HSPs. On the other hand, Cu SAzyme presents extraordinary multienzyme activities to induce reactive oxygen species (ROS) storm formation, which can damage the existing HSPs in cancer cells. Through a two-pronged strategy of SGLT inhibitor and ROS storm, LIK066-loaded Cu SAzyme shows high efficiency for comprehensive removal of HSPs to realize mild PTT.

引用

页数：9

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