In vitro degradation and biocompatibility evaluation of fully biobased thermoplastic elastomers consisting of poly(β-myrcene) and poly(L-lactide) as stent coating

被引：12

作者：

Wei, Zhiyong ^{[1
]}

Wang, Wenhuan ^{[1
]}

Zhou, Cheng ^{[1
]}

Jin, Chenhao ^{[1
]}

Leng, Xuefei ^{[1
]}

Li, Yang ^{[1
]}

Zhang, Xing ^{[2
,3
]}

Chen, Shanshan ^{[2
]}

Zhang, Bingchun ^{[2
]}

Yang, Ke ^{[2
]}

机构：

[1] Dalian Univ Technol, Sch Chem Engn, Dept Polymer Sci & Engn, State Key Lab Fine Chem,Liaoning Key Lab Polymer, Dalian 116024, Peoples R China

[2] Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China

[3] Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China

来源：

POLYMER DEGRADATION AND STABILITY | 2020年 / 179卷

基金：

国家重点研发计划;

关键词：

Drug eluting stent; Coating; Poly(beta-myrcene)-poly(L-lactide); Thermoplastic elastomers; DRUG-ELUTING STENT; COMB POLY(BETA-MYRCENE)-GRAFT-POLY(L-LACTIDE) COPOLYMERS; POLY(ETHYLENE CARBONATE); BIODEGRADABLE POLYMER; PLGA; POLYISOBUTYLENE; PREVENTION; THROMBOSIS; PLA;

D O I：

10.1016/j.polymdegradstab.2020.109254

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Currently coronary stent coating materials focus on biodegradable polymers requiring excellent performances, including biodegradability, cytocompatibility and hemocompatibility as well as ductility. To endow poly(L-lactide) (PLLA) with good ductility as stent coating, two kinds of high branched PLLA grafted copolymers with introduction of biobased poly(beta-myrcene) rubber segments were developed towards sent coating. The impacts of topological architectures (including linear comb and star comb) on physical properties, hydrolytic and enzymatic degradation behaviors, cytocompatibility, hemocompatibility and coating morphology were investigated. It was found that the nonbiodegradable poly(beta-myrcene) rubber segments delayed the degradation rate, and further decreased with more complex architectures. Proteinase K accelerated enzymatic degradation compared with hydrolytic degradation. Biocompatibility testing showed that the fully biobased thermoplastic elastomers possessed good cytocompatibility and hemocompatibility. Morphological characterization of stent coatings indicated that the linear comb and star comb PLLA grafted copolymers improved the surface smooth of pure PLLA coating. Thus, these highly branched fully biobased thermoplastic elastomers are promising to as potential coating materials in drug eluting stent. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：10

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