Targeting MET Exon 14 Skipping Alterations: Has Lung Cancer MET Its Match?

被引:6
|
作者
Yap, Timothy A. [1 ,2 ]
Popat, Sanjay [1 ,3 ]
机构
[1] Royal Marsden Hosp, London, England
[2] Inst Canc Res, London, England
[3] Imperial Coll London, Natl Heart & Lung Inst, London, England
关键词
ACQUIRED-RESISTANCE; AMPLIFICATION; INHIBITORS; MUTATIONS; CARCINOMA;
D O I
10.1016/j.jtho.2016.10.019
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:12 / 14
页数:3
相关论文
共 50 条
  • [31] Detection of MET exon 14 skipping mutations in non-small cell lung cancer: overview and community perspective
    Subramanian, Janakiraman
    Tawfik, Ossama
    EXPERT REVIEW OF ANTICANCER THERAPY, 2021, 21 (08) : 877 - 886
  • [32] MET exon 14 skipping defines a unique molecular class of non-small cell lung cancer
    Zheng, Difan
    Wang, Rui
    Ye, Ting
    Yu, Su
    Hu, Haichuan
    Shen, Xuxia
    Li, Yuan
    Ji, Hongbin
    Sun, Yihua
    Chen, Haiquan
    ONCOTARGET, 2016, 7 (27) : 41691 - 41702
  • [33] Novel MET exon 14 skipping analogs characterized in non-small cell lung cancer patients: A case study
    Shi, Minke
    Ma, Jing
    Feng, Meilin
    Liang, Lei
    Chen, Hongyuan
    Wang, Tao
    Xie, Zhenghua
    CANCER GENETICS, 2021, 256 : 62 - 67
  • [34] Safety of Tepotinib in Patients With MET Exon 14 Skipping NSCLC and Recommendations for Management
    Veillon, Remi
    Sakai, Hiroshi
    Le, Xiuning
    Felip, Enriqueta
    Cortot, Alexis B.
    Smit, Egbert F.
    Park, Keunchil
    Griesinger, Frank
    Britschgi, Christian
    Wu, Yi-Long
    Melosky, Barbara
    Baijal, Shobhit
    de Castro Jr, Gilberto
    Sedova, Michaela
    Berghoff, Karin
    Otto, Gordon
    Paik, Paul K.
    CLINICAL LUNG CANCER, 2022, 23 (04) : 320 - 332
  • [35] Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro
    Fujino, Toshio
    Kobayashi, Yoshihisa
    Suda, Kenichi
    Koga, Takamasa
    Nishino, Masaya
    Ohara, Shuta
    Chiba, Masato
    Shimoji, Masaki
    Tomizawa, Kenji
    Takemoto, Toshiki
    Mitsudomi, Tetsuya
    JOURNAL OF THORACIC ONCOLOGY, 2019, 14 (10) : 1753 - 1765
  • [36] Alterations in the PI3K Pathway Drive Resistance to MET Inhibitors in NSCLC Harboring MET Exon 14 Skipping Mutations
    Jamme, Philippe
    Fernandes, Marie
    Copin, Marie-Christine
    Descarpentries, Clotilde
    Escande, Fabienne
    Morabito, Angela
    Gregoire, Valerie
    Jamme, Matthieu
    Baldacci, Simon
    Tulasne, David
    Kherrouche, Zoulika
    Cortot, Alexis B.
    JOURNAL OF THORACIC ONCOLOGY, 2020, 15 (05) : 741 - 751
  • [37] Use of savolitinib as neoadjuvant therapy for non-small cell lung cancer patient with MET exon 14 skipping alterations: A case report
    Zhang, Yu
    Zhang, Hao
    Wang, Hanqing
    Zeng, Jingtong
    Zhang, Bo
    Zhou, Ning
    Zu, Lingling
    Song, Zuoqing
    Wang, Changli
    Xu, Song
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [38] Functional Analysis of MET Exon 14 Skipping Alteration in Cancer Invasion and Metastatic Dissemination
    Wang, Feng
    Liu, Yang
    Qiu, Wanglong
    Shum, Elaine
    Feng, Monica
    Zhao, Dejian
    Zheng, Deyou
    Borczuk, Alain
    Cheng, Haiying
    Halmos, Balazs
    CANCER RESEARCH, 2022, 82 (07) : 1365 - 1379
  • [39] Real world experience with MET inhibitors in MET exon 14 skipping mutated non-small cell lung cancer: largest Indian perspective
    Batra, Ullas
    Singh, Ajay Kumar
    Nathany, Shrinidhi
    Dewan, Abhinav
    Sharma, Mansi
    Amrith, B. P.
    Mehta, Anurag
    Batra, Vanshika
    Noronha, Vanita
    Prabhash, Kumar
    DISCOVER ONCOLOGY, 2025, 16 (01)
  • [40] Characterization of MET Exon 14 Skipping Alterations (in NSCLC) and Identification of Potential Therapeutic Targets Using Whole Transcriptome Sequencing
    Kim, So Yeon
    Yin, Jun
    Bohlman, Stephen
    Walker, Phillip
    Dacic, Sanja
    Kim, Chul
    Khan, Hina
    Liu, Stephen V.
    Ma, Patrick C.
    Nagasaka, Misako
    Reckamp, Karen L.
    Abraham, Jim
    Uprety, Dipesh
    Wang, Feng
    Xiu, Joanne
    Zhang, Jian
    Cheng, Haiying
    Halmos, Balazs
    JTO CLINICAL AND RESEARCH REPORTS, 2022, 3 (09):