Regulators of innate immunity as novel targets for panviral therapeutics

被引：24
作者：
Es-Saad, Salwa [1 ]
Tremblay, Nicolas [1 ]
Baril, Martin [1 ]
Lamarre, Daniel [1 ,2 ]
机构：
[1] IRIC, Montreal, PQ, Canada
[2] Univ Montreal, Fac Med, Montreal, PQ H3C 3J7, Canada
来源：
CURRENT OPINION IN VIROLOGY | 2012年 / 2卷 / 05期
关键词：
TOLL-LIKE RECEPTORS; I-LIKE RECEPTORS; INTERFERON-LAMBDA; GENETIC-VARIATION; RNA RECOGNITION; DENDRITIC CELLS; VACCINE; INFECTION; MICRORNAS; SAFETY;
D O I：
10.1016/j.coviro.2012.08.009
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Interferons (IFNs) have long been used as an immunomodulatory therapy for a large array of acute and chronic viral infections. However, IFN therapies have been plagued by severe side effects. The discovery of pathogen recognition receptors (PRR) rejuvenated the interest for immunomodulatory therapies. The successes obtained with Toll-like receptor (TLR) agonists in activating immune cells and as adjuvant for prophylactic vaccines against different viruses paved the way to targeted immunomodulatory therapy. Better characterization of pathogen-induced immune disorders and newly discovered regulators of innate immunity have now the potential to specifically withdraw prevailing subversion mechanisms and to transform antiviral treatments by introducing panviral therapeutics with less adverse effects than IFN therapies.
引用
收藏
页码：622 / 628
页数：7
相关论文
共 56 条
[1]   Comparative efficacy and overall safety of different doses of consensus interferon for treatment of chronic HCV infection: a systematic review and meta-analysis [J].
Alavian, Seyed-Moayed ;
Behnava, Bita ;
Tabatabaei, Seyed Vahid .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2010, 66 (11) :1071-1079
[2]  
Ashour MKF, 2011, AM ASS STUDY LIVER D
[3]   Randomised clinical trial: anti-viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV [J].
Bergmann, J. F. ;
de Bruijne, J. ;
Hotho, D. M. ;
de Knegt, R. J. ;
Boonstra, A. ;
Weegink, C. J. ;
van Vliet, A. A. ;
van de Wetering, J. ;
Fletcher, S. P. ;
Bauman, L. A. ;
Rahimy, M. ;
Appleman, J. R. ;
Freddo, J. L. ;
Janssen, H. L. A. ;
Reesink, H. W. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 34 (04) :443-453
[4]   The Structural Biology of Toll-like Receptors [J].
Botos, Istvan ;
Segal, David M. ;
Davies, David R. .
STRUCTURE, 2011, 19 (04) :447-459
[5]   Gold nanorod delivery of an ssRNA immune activator inhibits pandemic H1N1 influenza viral replication [J].
Chakravarthy, Krishnan V. ;
Bonoiu, Adela C. ;
Davis, William G. ;
Ranjan, Priya ;
Ding, Hong ;
Hu, Rui ;
Bowzard, J. Bradford ;
Bergey, Earl J. ;
Katz, Jacqueline M. ;
Knight, Paul R. ;
Sambhara, Suryaprakash ;
Prasad, Paras N. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (22) :10172-10177
[6]   Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination [J].
Desmet, Christophe J. ;
Ishii, Ken J. .
NATURE REVIEWS IMMUNOLOGY, 2012, 12 (07) :479-491
[7]   AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity [J].
Didierlaurent, Arnaud M. ;
Morel, Sandra ;
Lockman, Laurence ;
Giannini, Sandra L. ;
Bisteau, Michel ;
Carlsen, Harald ;
Kielland, Anders ;
Vosters, Olivier ;
Vanderheyde, Nathalie ;
Schiavetti, Francesca ;
Larocque, Daniel ;
Van Mechelen, Marcelle ;
Garcon, Nathalie .
JOURNAL OF IMMUNOLOGY, 2009, 183 (10) :6186-6197
[8]   Interferon-Lambda: A New Addition to an Old Family [J].
Donnelly, Raymond P. ;
Kotenko, Sergei V. .
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2010, 30 (08) :555-564
[9]   Regulation of RLR-mediated innate immune signaling - It is all about keeping the balance [J].
Eisenaecher, Katharina ;
Krug, Anne .
EUROPEAN JOURNAL OF CELL BIOLOGY, 2012, 91 (01) :36-47
[10]   Albinterferon-alfa 2b: a new treatment option for hepatitis C [J].
Flisiak, Robert ;
Flisiak, Iwona .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2010, 10 (10) :1509-1515
123456