Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer

被引：104

作者：

Chu, Jennifer ^{[1
]}

Cargnello, Marie ^{[2
,3
]}

Topisirovic, Ivan ^{[1
,2
,3
]}

Pelletier, Jerry ^{[1
,3
,4
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ, Canada

[2] McGill Univ, Lady Davis Inst, SMBD JGH, Montreal, PQ, Canada

[3] McGill Univ, Gerald Bronfman Dept Oncol, Montreal, PQ, Canada

[4] McGill Univ, Rosalind & Morris Goodman Canc Res Ctr, Montreal, PQ, Canada

来源：

TRENDS IN CELL BIOLOGY | 2016年 / 26卷 / 12期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

CAP-DEPENDENT TRANSLATION; TRANSFORMATION SUPPRESSOR PDCD4; GUANINE-NUCLEOTIDE EXCHANGE; MESSENGER-RNA TRANSLATION; EUKARYOTIC INITIATION; MALIGNANT-TRANSFORMATION; CELL-SURVIVAL; FACTOR; 4B; GENE AMPLIFICATION; ER STRESS;

D O I：

10.1016/j.tcb.2016.06.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Control of mRNA translation plays a crucial role in the regulation of gene expression and is critical for cellular homeostasis. Dysregulation of translation initiation factors has been documented in several pathologies including cancer. Aberrant function of translation initiation factors leads to translation reprogramming that promotes proliferation, survival, angiogenesis, and metastasis. In such context, understanding how altered levels (and presumably activity) of initiation factors can contribute to tumor initiation and/or maintenance is of major interest for the development of novel therapeutic strategies. In this review we provide an overview of translation initiation mechanisms and focus on recent findings describing the role of individual initiation factors and their aberrant activity in cancer.

引用

收藏

页码：918 / 933

页数：16

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