Laurene-type sesquiterpenes from the Red Sea red alga Laurencia obtusa as potential antitumor-antimicrobial agents

被引：36

作者：

Alarif, Walied M. ^{[1
]}

Al-Lihaibi, Sultan S. ^{[1
]}

Ayyad, Seif-Eldin N. ^{[2
]}

Abdel-Rhman, Mohamed H. ^{[3
]}

Badria, Farid A. ^{[4
]}

机构：

[1] King Abdulaziz Univ, Fac Marine Sci, Dept Marine Chem, Jeddah 21589, Saudi Arabia

[2] King Abdulaziz Univ, Fac Sci, Dept Chem, Jeddah 21589, Saudi Arabia

[3] Mansoura Univ, Fac Sci, Dept Chem, Mansoura, Egypt

[4] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷

关键词：

Marine algae; Terpenoids; Gram-positive bacteria; Candida albicans; EAC; ANTIBACTERIAL ACTIVITY; HALOGENATED METABOLITES;

D O I：

10.1016/j.ejmech.2012.06.060

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new laurene-type sesquiterpenes, 12-hydroxy isolaurene (1), 8,11-dihydro-12-hydroxy isolaurene (2) and isolauraldehyde (3) were isolated from the organic extract of the red alga Laurencia obtusa. The chemical structures of isolates were determined by interpretation of their spectral data 1D and 2D NMR, UV, IR and MS. The newly isolated compounds were tested for their antimicrobial and antitumor activities. Compounds (1-3) exhibited potent activity against the Gram-positive Bacillus subtilis and Staphylococcus aureus, where 3 proved to be the most active (MIC 35 and 27 mu g/mL, respectively). Moreover, compound 3 exhibited a significant activity against Candida albicans (MIC of 70 mu g/mL) and revealed to have very promising activity in an in vitro model of Ehrlich ascites Carcinoma. (C) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：462 / 466

页数：5

共 23 条

[1]

Ayyad SEN, 2011, CHEM PHARM BULL, V59, P1294, DOI 10.1248/cpb.59.1294

[2] Marine natural products as prototype insecticidal agents [J].

ElSayed, KA ;

Dunbar, DC ;

Perry, TL ;

Wilkins, SP ;

Hamann, MT .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1997, 45 (07) :2735-2739

[3] CYTO-TOXIC AND ANTITUMOR ACTIVITIES OF RABDOSIA DITERPENOIDS [J].

FUJITA, T ;

TAKEDA, Y ;

SUN, HD ;

MINAMI, Y ;

MARUNAKA, T ;

TAKEDA, S ;

YAMADA, Y ;

TOGO, T .

PLANTA MEDICA, 1988, (05) :414-417

[4]

GRUICKSHANK R, 1975, MED MICROBIOLOGY, V11, P190

[5]

HOWARD BM, 1975, TETRAHEDRON LETT, P1687

[6]

Irie T., 1975, TETRAHEDRON LETT, V6, P3619

[7]

Kayaalp O, 1996, TIBBI FARMAKOLOJI

[8] New sesquiterpenes from the red alga Laurencia microcladia [J].

Kladi, Maria ;

Vagias, Constantinos ;

Papazafiri, Panagiota ;

Furnari, Giovanni ;

Serio, Donatella ;

Roussis, Vassilios .

TETRAHEDRON, 2007, 63 (32) :7606-7611

[9] Sesquiterpene content of the antibacterial dichloromethane extract of the marine red alga Laurencia obtusa [J].

Konig, GM ;

Wright, AD .

PLANTA MEDICA, 1997, 63 (02) :186-187

[10]

Li HY, 1998, CURR ORG CHEM, V2, P649

← 1 2 3 →