Curcumin: An epigenetic regulator and its application in cancer

被引：81
作者：
Ming, Tianqi [1 ]
Tao, Qiu [1 ]
Tang, Shun [1 ]
Zhao, Hui [1 ]
Yang, Han [1 ]
Liu, Maolun [1 ]
Ren, Shan [1 ]
Xu, Haibo [1 ,2 ]
机构：
[1] Chengdu Univ Tradit Chinese Med, Dept Pharmacol, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
[2] Chengdu Univ Tradit Chinese Med, Sch Pharmaceut Sci, Dept Pharmacol, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 156卷
基金：
中国国家自然科学基金;
关键词：
Curcumin; Epigenetics; Cancer; Bioavailability; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN PROSTATE-CANCER; LUNG-CANCER; INHIBITS PROLIFERATION; DIETARY PHYTOCHEMICALS; PROMOTER METHYLATION; HISTONE DEACETYLASE; DNA METHYLATION; SERUM-ALBUMIN; IN-VITRO;
D O I：
10.1016/j.biopha.2022.113956
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Nowadays, one of the leading causes of death in humans is cancer, which is still on the rise globally and is in great need of intense study on the pathogenic mechanism and effective therapy. Epigenetics is a discipline that studies heritable changes in gene expression without alteration of DNA sequence. Epigenetic changes mainly involve DNA methylation, histone modifications and non-coding RNA (ncRNA) expression, which are inter-connected to play a crucial role in the initiation and progression of various malignancies. Curcumin is a type of plant-derived polyphenolic compound with strong bioactivity against various disorders, particularly cancer. Retrieving commonly used databases such as PubMed, Google Scholar and CNKI, we summarized recent ad-vances in the efficacy of curcumin on cancer and its epigenetic regulation in terms of DNA methylation, histone modifications and ncRNA expression. Furthermore, we also focused on improving the bioavailability of curcumin by development of novel curcumin analogs with high bioavailability, nanoparticles-loaded drug delivery system for curcumin, and combination therapy of curcumin with other agents. This review provides comprehensive insights into the molecular mechanisms, on the basis of epigenetic regulation, underlying the clinical application of curcumin in cancer.
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页数：13
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