α-glucosidase inhibitors ellagic acid derivatives with immunoinhibitory properties from Terminalia superba

被引：22

作者：

Tabopda, Turibio Kuiate ^{[1
,2
]}

Ngoupayo, Joseph ^{[1
]}

Liu, Jiawei ^{[2
]}

Ali, Muhammad Shaiq ^{[3
]}

Khan, Shamsun Nahar ^{[3
]}

Ngadjui, Bonaventure Tchaleu ^{[1
]}

Luu, Bang ^{[2
]}

机构：

[1] Univ Yaounde, Dept Chim Organ, Yaounde, Cameroon

[2] Univ Strasbourg 1, Lab Chim Organ Substances Nat, UMR 7177, CNRS, F-67084 Strasbourg, France

[3] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 06期

关键词：

alpha-glucosidase; immunomodulatory activity; ellagic acid; Terminalia superba;

D O I：

10.1248/cpb.56.847

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fractionation of stem barks of Terminalia superba yielded two new ellagic acid derivatives, 3,4'-di-O-methylellagic acid 3'-O-beta-D-xylopyranoside (1) and 4'-O-galloy-3,3'-di-O-methylellagic acid 4-O-beta-D-xylopyranoside (2) together with known 3,3'-di-O-methylellagic acid, ellagic acid and 3,3'-di-O-methylellagic acid 4'-O-beta-D-xylopyranoside. Compounds (1) and (2) showed significant m-glucosidase inhibition activity and possessed significant immunoinhibitory activities with no cytotoxic effects.

引用

页码：847 / 850

页数：4

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