α-glucosidase inhibitors ellagic acid derivatives with immunoinhibitory properties from Terminalia superba

被引：22
|
作者：
Tabopda, Turibio Kuiate [1 ,2 ]
Ngoupayo, Joseph [1 ]
Liu, Jiawei [2 ]
Ali, Muhammad Shaiq [3 ]
Khan, Shamsun Nahar [3 ]
Ngadjui, Bonaventure Tchaleu [1 ]
Luu, Bang [2 ]
机构：
[1] Univ Yaounde, Dept Chim Organ, Yaounde, Cameroon
[2] Univ Strasbourg 1, Lab Chim Organ Substances Nat, UMR 7177, CNRS, F-67084 Strasbourg, France
[3] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 06期
关键词：
alpha-glucosidase; immunomodulatory activity; ellagic acid; Terminalia superba;
D O I：
10.1248/cpb.56.847
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fractionation of stem barks of Terminalia superba yielded two new ellagic acid derivatives, 3,4'-di-O-methylellagic acid 3'-O-beta-D-xylopyranoside (1) and 4'-O-galloy-3,3'-di-O-methylellagic acid 4-O-beta-D-xylopyranoside (2) together with known 3,3'-di-O-methylellagic acid, ellagic acid and 3,3'-di-O-methylellagic acid 4'-O-beta-D-xylopyranoside. Compounds (1) and (2) showed significant m-glucosidase inhibition activity and possessed significant immunoinhibitory activities with no cytotoxic effects.
引用
收藏
页码：847 / 850
页数：4
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