Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents

被引：40

作者：

Canaday, David H. ^{[1
,2
]}

Carias, Lenore ^{[1
]}

Oyebanji, Oladayo A. ^{[1
]}

Keresztesy, Debbie ^{[1
]}

Wilk, Dennis ^{[1
]}

Payne, Michael ^{[1
]}

Aung, Htin ^{[1
]}

St Denis, Kerri ^{[3
]}

Lam, Evan C. ^{[3
]}

Rowley, Christopher F. ^{[4
]}

Berry, Sarah D. ^{[5
]}

Cameron, Cheryl M. ^{[1
]}

Cameron, Mark J. ^{[1
]}

Wilson, Brigid ^{[2
]}

Balazs, Alejandro B. ^{[3
]}

Gravenstein, Stefan ^{[6
,7
]}

King, Christopher L. ^{[1
,8
]}

机构：

[1] Case Western Reserve Univ, Sch Med, 10900 Euclid Ave,BRB 1022, Cleveland, OH 44106 USA

[2] Cleveland Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Cleveland, OH USA

[3] MIT & Harvard, Ragon Inst, Massachusetts Gen Hosp, Cambridge, MA USA

[4] Beth Israel Deaconess Med Ctr, Div Infect Dis, Boston, MA 02215 USA

[5] Hebrew SeniorLife, Marcus Inst Aging Res, Boston, MA USA

[6] Brown Univ, Div Geriatr & Palliat Med, Alpert Med Sch, Providence, RI 02912 USA

[7] Providence Vet Affairs Med Ctr, Ctr Innovat Long Term Serv & Supports, Providence, RI USA

[8] Cleveland Vet Affairs Med Ctr, Div Infect Dis, Cleveland, OH USA

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 73卷 / 11期

基金：

美国国家卫生研究院;

关键词：

SARS-CoV-2; geriatrics; vaccine; COVID-19;

D O I：

10.1093/cid/ciab447

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents and 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-naive nursing home residents' median post-second vaccine dose antibody neutralization titers are one-quarter that of SARS-CoV-2-naive healthcare workers.

引用

页码：2112 / 2115

页数：4

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