Fractal dimension analysis of MR images reveals grey matter structure irregularities in schizophrenia

被引：61

作者：

Sandu, Anca-Larisa ^{[1
]}

Rasmussen, Inge-Andre, Jr. ^{[2
]}

Lundervold, Arvid ^{[3
]}

Kreuder, Frank ^{[4
]}

Neckelmann, Gesche ^{[5
]}

Hugdahl, Kenneth ^{[1
,6
]}

Specht, Karsten ^{[1
,7
]}

机构：

[1] Univ Bergen, Dept Biol & Med Psychol, N-5009 Bergen, Norway

[2] Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, N-7034 Trondheim, Norway

[3] Univ Bergen, Dept Biomed, Bergen, Norway

[4] Univ Trier, Ctr Neuropsychol Res, Trier, Germany

[5] Haukeland Hosp, Dept Radiol, N-5021 Bergen, Norway

[6] Haukeland Hosp, Dept Psychiat, N-5021 Bergen, Norway

[7] Haukeland Hosp, Dept Med Engn, N-5021 Bergen, Norway

来源：

COMPUTERIZED MEDICAL IMAGING AND GRAPHICS | 2008年 / 32卷 / 02期

关键词：

fractal dimension; brain imaging; schizophrenia;

D O I：

10.1016/j.compmedimag.2007.10.005

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The fractal dimension (FD) was used to reveal brain structure irregularities in patients with schizophrenia. FD provides a unique way of quantifying the shape complexity of cortical folding of the human brain. MR images were obtained from seven patients with schizophrenia that were compared with six healthy control subjects. The MR images were first segmented, and the FD was calculated for the grey/white matter boundary for the whole brain and the hemispheres separately, using the box-counting and Minkowski-Bouligand methods. The results showed that the patients had larger FD values than the controls, for the whole brain volume and right hemisphere. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：150 / 158

页数：9

共 46 条

[21] Is the brain cortex a fractal? [J].