The Therapeutic Implications of Renin-Angiotensin System Blockade in Diabetic Retinopathy

被引：1
作者：
Jeganathan, V. Swetha E. [1 ]
机构：
[1] Univ Coll Hosp Galway, Dept Ophthalmol, Galway, Ireland
来源：
CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2011年 / 12卷 / 03期
关键词：
Blood pressure; diabetes mellitus; renin-angiotensin-system; diabetic retinopathy; DIRECT; NAVIGATOR; DREAM; EUCLID; IMPAIRED GLUCOSE-TOLERANCE; FASTING GLUCOSE; ALDOSTERONE SYSTEM; BLOOD-PRESSURE; DREAM TRIAL; RECEPTOR; PEOPLE; ROSIGLITAZONE; NEPHROPATHY; INHIBITION;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Research has proven that blood pressure is an important modifiable risk factor for diabetic retinopathy and that lowering high blood pressure significantly reduces the development and progression of retinopathy in both type 1 and type 2 diabetic patients. The renin-angiotensin-system (RAS) has been shown to become activated in diabetes. Hyperglycemia stimulates the angiotensin AT1-receptor and downstream chains of events resulting in diabetic end organ damage. Pharmacological RAS inhibition may thus be a beneficial therapeutic strategy in the management of diabetic retinopathy. The present review article details therapeutic RAS inhibition in diabetic retinopathy with an emphasis on recently published evidence. Future research on the potential effects of RAS blockade will be important while using these drugs as adjuncts in the treatment of diabetic retinopathy.
引用
收藏
页码：392 / 395
页数：4
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