Masters or slaves? Vesicle release machinery and the regulation of presynaptic calcium channels

被引：47
作者：
Jarvis, SE
Zamponi, GW
机构：
[1] Univ Calgary, Dept Physiol & Biophys, Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada
[2] Univ Calgary, Dept Pharmacol & Therapeut, Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada
来源：
CELL CALCIUM | 2005年 / 37卷 / 05期
关键词：
Ca2+ channels; syntaxin; SNARE proteins; neurotransmission;
D O I：
10.1016/j.ceca.2005.01.017
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Calcium entry through presynaptic voltage-gated calcium channels is essential for neurotransmitter release. The two major types of presynaptic calcium channels contain a synaptic protein interaction site that physically interacts with synaptic vesicle release proteins. This is thought to tighten the coupling between the sources of calcium entry and the neurotransmitter release machinery. Conversely, the binding of synaptic proteins to presynaptic calcium channels regulates calcium channel activity. Hence, presynaptic calcium channels act not only as the masters of the synaptic release process, but also as key targets for feedback inhibition. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：483 / 488
页数：6
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