Intramolecular Ring-Opening of Oxetanes: Access to Functionalised Hydroxymethyl 2,3-Dihydroimidazo[1,2-c ]quinazolines

被引：5

作者：

Bagal, Sharan K. ^{[1
]}

Bodnarchuk, Michael S. ^{[1
]}

King, Thomas A. ^{[1
]}

McKerrecher, Darren ^{[1
]}

Luo, Xuehong ^{[2
]}

Wang, Peng ^{[2
]}

Steward, Oliver R. ^{[1
]}

机构：

[1] AstraZeneca, Oncol R&D, Chem, Cambridge, England

[2] Pharmaron Beijing Co Ltd, 6 Taihe Rd BDA, Beijing, Peoples R China

来源：

SYNLETT | 2020年 / 31卷 / 05期

关键词：

oxetane ring-opening; intramolecular cyclization; imidazoquinazolines; one-pot synthesis;

D O I：

10.1055/s-0039-1691578

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An intramolecular oxetane ring-opening was developed, affording novel 2-(hydroxymethyl)-2,3-dihydroimidazo[1,2- c ]quinazolines from N -(3-methyloxetan-3-yl)quinazolin-4-amines under mild conditions. The resulting medicinally relevant tricyclic scaffolds were synthesised in good yields with diverse substituents. Moreover, reaction optimisation led to the development of a one-pot procedure.

引用

页码：502 / 506

页数：5

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