Cytochrome p450 2E1, but not NADPH oxidase is required for ethanol-induced DNA damage and upregulation of DNA repair genes in mouse liver.

被引:0
|
作者
Rusyn, I
Kono, H
Kosyk, O
Bradford, BU
机构
[1] Univ N Carolina, Chapel Hill, NC 27515 USA
[2] Yamanashi Univ, Tamaho, Yamanashi, Japan
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
522
引用
收藏
页码:410A / 410A
页数:1
相关论文
共 50 条
  • [31] Methylation of cytochrome p450 2E1 promoter induced by low dosage of isoniazid
    Shen, Lihong
    Zhang, Bing
    Sun, Shufeng
    Feng, Fumin
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2013, 36 (01) : 149 - 151
  • [32] Inducers of cytochrome P450 2E1 enhance methotrexate-induced hepatocytotoxicity
    Neuman, MG
    Cameron, RG
    Haber, JA
    Katz, GG
    Malkiewicz, IM
    Shear, NH
    CLINICAL BIOCHEMISTRY, 1999, 32 (07) : 519 - 536
  • [33] THE CYTOCHROME P450 2E1 INHIBITOR CHLORMETHIAZOLE INHIBITS HEPATIC ETHANOL-MEDIATED CARCINOGENESIS INDUCED BY DIETHYLNITROSAMINE
    Ye, Q.
    Lian, F.
    Chavez, P. R. G.
    Chung, J.
    Ling, W.
    Seitz, H. K.
    Wang, X. D.
    ALCOHOL AND ALCOHOLISM, 2011, 46 : 32 - 32
  • [34] ATF4 AND THE INTEGRATED STRESS RESPONSE ARE INDUCED BY ETHANOL AND CYTOCHROME P450 2E1 IN HUMAN HEPATOCYTES
    Magne, L.
    Blanc, E.
    Legrand, B.
    Barouki, R.
    Rouach, H.
    Garlatti, M.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2010, 34 (08) : 80A - 80A
  • [35] ATF4 and the integrated stress response are induced by ethanol and cytochrome P450 2E1 in human hepatocytes
    Magne, Laurent
    Blanc, Etienne
    Legrand, Beatrice
    Lucas, Daniele
    Barouki, Robert
    Rouach, Helene
    Garlatti, Michele
    JOURNAL OF HEPATOLOGY, 2011, 54 (04) : 729 - 737
  • [36] SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease
    Tomasi, Maria Lauda
    Ramani, Komal
    Ryoo, Minjung
    Cossu, Carla
    Floris, Andrea
    Murray, Ben J.
    Iglesias-Ara, Ainhoa
    Spissu, Ylenia
    Mavila, Nirmala
    FASEB JOURNAL, 2018, 32 (06): : 3278 - 3288
  • [37] Differences in sensitivity of cultured rat brain neuronal and glial cytochrome P450 2E1 to ethanol
    Kapoor, Nidhi
    Pant, Aditya B.
    Dhawan, Alok
    Dwievedi, Uppendra N.
    Gupta, Yogendra K.
    Seth, Prahlad K.
    Parmar, Devendra
    LIFE SCIENCES, 2006, 79 (16) : 1514 - 1522
  • [38] DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver
    Kronfol, Mohamad M.
    Jahr, Fay M.
    Dozmorov, Mikhail G.
    Phansalkar, Palak S.
    Xie, Lin Y.
    Aberg, Karolina A.
    McRae, MaryPeace
    Price, Elvin T.
    Slattum, Patricia W.
    Gerk, Philip M.
    McClay, Joseph L.
    GEROSCIENCE, 2020, 42 (03) : 819 - 832
  • [39] Heterologous expression of mouse cytochrome P450 2e1 in V79 cells: Construction and characterisation of the cell line and comparison with V79 cell lines stably expressing rat P450 2E1 and human P450 2E1
    Bernauer, U
    Glatt, H
    Heinrich-Hirsch, B
    Liu, YG
    Muckel, E
    Vieth, B
    Gundert-Remy, U
    ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 2003, 31 (01): : 21 - 30
  • [40] DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver
    Mohamad M. Kronfol
    Fay M. Jahr
    Mikhail G. Dozmorov
    Palak S. Phansalkar
    Lin Y. Xie
    Karolina A. Aberg
    MaryPeace McRae
    Elvin T. Price
    Patricia W. Slattum
    Philip M. Gerk
    Joseph L. McClay
    GeroScience, 2020, 42 : 819 - 832