Mesenchymal-epithelial transition in development and reprogramming

被引：208
作者：
Pei, Duanqing [1 ,2 ]
Shu, Xiaodong [1 ,2 ]
Gassama-Diagne, Ama [3 ,4 ]
Thiery, Jean Paul [1 ,5 ,6 ,7 ,8 ]
机构：
[1] Chinese Acad Sci, Guangdong Prov Key Lab Stem Cell & Regenerat Med, South China Inst Stem Cell Biol & Regenerat Med, CAS Key Lab Regenerat Biol,Guangzhou Inst Biomed, Guangzhou, Guangdong, Peoples R China
[2] GIBH, Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou, Guangdong, Peoples R China
[3] INSERM, U1193, Villejuif, France
[4] Univ Paris Sud, UMR S 1193, Villejuif, France
[5] Natl Univ Singapore, Dept Biochem, Yong Loo Lin Sch Med, Singapore, Singapore
[6] Univ Paris Denis Diderot, CNRS, UMR 7057 Matter & Complex Syst, Paris, France
[7] Inst Gustave Roussy, INSERM, U1186, Ctr Comprehens Canc, Villejuif, France
[8] Chinese Acad Sci, Drug Discovery Pipeline, Guangzhou Inst Biomed & Hlth, Guangzhou, Guangdong, Peoples R China
来源：
NATURE CELL BIOLOGY | 2019年 / 21卷 / 01期
基金：
中国国家自然科学基金;
关键词：
E-CADHERIN; CELL POLARITY; PLASMA-MEMBRANE; MICROTUBULE DYNAMICS; ADHERENS JUNCTIONS; HUMAN FIBROBLASTS; PROGENITOR CELLS; SOMATIC-CELLS; CANCER-CELLS; STEM-CELLS;
D O I：
10.1038/s41556-018-0195-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial-mesenchymal transition. The reverse process, mesenchymal-epithelial transition (MET), can similarly generate epithelial cells. Transitions between epithelial and mesenchymal states are also critical for the induction of pluripotent stem cells from somatic cells. This Review discusses the relatively less characterized process of MET, focusing on the genesis of apicobasal cell polarity and exploring the roles of MET in development and reprogramming.
引用
收藏
页码：44 / 53
页数：10
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