Frequent overexpression of cyclin D2/cyclin-dependent kinase 4 in Wilms' tumor

被引：28

作者：

Faussillon, M ^{[1
]}

Monnier, L ^{[1
]}

Junien, C ^{[1
]}

Jeanpierre, C ^{[1
]}

机构：

[1] Univ Paris 05, Hop Necker Enfants Malad, INSERM U383, F-75743 Paris, France

来源：

CANCER LETTERS | 2005年 / 221卷 / 01期

关键词：

Wilms' tumor; overexpression; cyclin D2; cyclin-dependent kinase 4;

D O I：

10.1016/j.canlet.2004.08.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The expression status of the three cyclin D genes (CCND1, CCND2 and CCND3), the two cyclin D-dependent kinase genes (CDK4 and CDK6) and the p16(INK4a) gene was studied in a series of 47 Wilms' tumors, 16 normal mature kidneys and two fetal kidneys. We showed predominant overexpression of CCND2 and CDK4 compared to CCND1/D3 and CDK6 respectively. We found a specific correlation between relapse and CDK4 overexpression, but not CDK6 overexpression. We did not identify any methylation of the p16(INK4a) promoter. This suggests that dysregulation of CCND2 and CDK4 plays a specific role in WT tumorigenesis. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：67 / 75

页数：9

共 33 条

[1] Gene amplification and overexpression of CDK4 in sporadic breast carcinomas is associated with high tumor cell proliferation [J].

An, HX ;

Beckmann, MW ;

Reifenberger, G ;

Bender, HG ;

Niederacher, D .

AMERICAN JOURNAL OF PATHOLOGY, 1999, 154 (01) :113-118

[2]

Arcellana-Panlilio MY, 2000, GENE CHROMOSOME CANC, V29, P63, DOI 10.1002/1098-2264(2000)9999:9999<::AID-GCC1006>3.0.CO

[3]

2-L

[4] CHARACTERIZATION OF REGIONS OF CHROMOSOME-12 AND CHROMOSOME-16 INVOLVED IN NEPHROBLASTOMA TUMORIGENESIS [J].

AUSTRUY, E ;

CANDON, S ;

HENRY, I ;

GYAPAY, G ;

TOURNADE, MF ;

MANNENS, M ;

CALLEN, D ;

JUNIEN, C ;

JEANPIERRE, C .

GENES CHROMOSOMES & CANCER, 1995, 14 (04) :285-294

[5]

Baudry D, 2000, CLIN CANCER RES, V6, P3957

[6] Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion [J].

Coller, HA ;

Grandori, C ;

Tamayo, P ;

Colbert, T ;

Lander, ES ;

Eisenman, RN ;

Golub, TR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3260-3265

[7] Principles of Wilms' tumor biology [J].

Coppes, MJ ;

Pritchard-Jones, K .

UROLOGIC CLINICS OF NORTH AMERICA, 2000, 27 (03) :423-+

[8]

Englert C, 1997, CANCER RES, V57, P1429

[9]

Gemma A, 1996, INT J CANCER, V68, P605, DOI 10.1002/(SICI)1097-0215(19961127)68:5<605::AID-IJC9>3.0.CO

[10]

2-2

← 1 2 3 4 →