Real-world Multicenter Analysis of Clinical Outcomes and Safety of Meropenem-Vaborbactam in Patients Treated for Serious Gram-Negative Bacterial Infections

被引:46
作者
Alosaimy, Sara [1 ]
Jorgensen, Sarah C. J. [1 ,12 ]
Lagnf, Abdalhamid M. [1 ]
Melvin, Sarah [1 ]
Mynatt, Ryan P. [2 ,13 ]
Carlson, Travis J. [3 ,14 ]
Garey, Kevin W. [3 ]
Allen, David [4 ]
Venugopalan, Veena [5 ]
Veve, Michael [6 ,7 ]
Athans, Vasilios [8 ]
Saw, Stephen [8 ]
Yost, Christine N. [9 ]
Davis, Susan L. [1 ,10 ]
Rybak, Michael J. [1 ,2 ,11 ]
机构
[1] Wayne State Univ, Dept Pharm Practice, Eugene Applebaum Coll Pharm & Hlth Sci, Antiinfect Res Lab, Detroit, MI USA
[2] Detroit Med Ctr, Dept Pharm Serv, Detroit, MI USA
[3] Univ Houston, Coll Pharm, Houston, TX 77030 USA
[4] Inova Fairfax Med Campus, Dept Pharm, Falls Church, VA USA
[5] Univ Florida, Coll Pharm, Gainesville, FL USA
[6] Univ Tennessee, Coll Pharm, Knoxville, TN USA
[7] Univ Tennessee, Med Ctr, Knoxville, TN USA
[8] Hosp Univ Penn, 3400 Spruce St, Philadelphia, PA 19104 USA
[9] Beaumont Hosp, Royal Oak, MI USA
[10] Henry Ford Hosp, Dept Pharm, Detroit, MI 48202 USA
[11] Wayne State Univ, Sch Med, Dept Med, Div Infect Dis, Detroit, MI 48201 USA
[12] Mt Sinai Hosp, Toronto, ON, Canada
[13] Univ Kentucky Healthcare, Lexington, KY USA
[14] High Point Univ, Fred Wilson Sch Pharm, High Point, NC USA
关键词
carbapenem-resistant Enterobacteriaceae; Gram-negative infections; meropenem-vaborbactam; multidrug-resistant; SEVERE SEPSIS;
D O I
10.1093/ofid/ofaa051
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Fourty patients were treated with meropenem-vaborbactam (MEV) for serious Gram-negative bacterial (GNB) infections. Carbapenem-resistant Enterobacteriaceae (CRE) comprised 80.0% of all GNB infections. Clinical success occurred in 70.0% of patients. Mortality and recurrence at 30 days were 7.5% and 12.5%, respectively. One patient experienced a probable rash due to MEV.
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