Exosomes: natural nanoparticles as bio shuttles for RNAi delivery

被引：57

作者：

Darband, Saber Ghazizadeh ^{[1
]}

Mirza-Aghazadeh-Attari, Mohammad ^{[2
,3
]}

Kaviani, Mojtaba ^{[4
]}

Mihanfar, Ainaz ^{[5
]}

Sadighparvar, Shirin ^{[6
]}

Yousefi, Bahman ^{[7
,8
]}

Majidinia, Maryam ^{[9
,10
]}

机构：

[1] Urmia Univ Med Sci, Hlth Technol Dev Ctr, Danesh Pey Hadi Co, Orumiyeh, Iran

[2] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran

[3] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran

[4] Acadia Univ, Sch Nutr & Dietet, Wolfville, NS, Canada

[5] Urmia Univ Med Sci, Dept Biochem, Fac Med, Orumiyeh, Iran

[6] Urmia Univ Med Sci, Neurophysiol Res Ctr, Orumiyeh, Iran

[7] Tabriz Univ Med Sci, Mol Med Res Ctr, Tabriz, Iran

[8] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[9] Urmia Univ Med Sci, Solid Tumor Res Ctr, Orumiyeh, Iran

[10] Urmia Univ Med Sci, Student Res Comm, Orumiyeh, Iran

来源：

JOURNAL OF CONTROLLED RELEASE | 2018年 / 289卷

关键词：

Exosomes; miRNA; siRNA; Gene transferring; Vehicle; CELL-DERIVED EXOSOMES; MEDIATED GENE-THERAPY; EXTRACELLULAR VESICLES; IN-VIVO; VIRAL VECTORS; STROMAL CELLS; RETICULOCYTE MATURATION; MIMETIC NANOVESICLES; MICRORNA TRANSFER; NONCODING RNAS;

D O I：

10.1016/j.jconrel.2018.10.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Application of exosomes, natural nanoscale vesicles, as specific delivery vehicles has received considerable attention in recent past years. The presence of various adhesive proteins on the surface of these lipid bilayers, gives them the ability to interact with cellular membranes. Although the function of exosomes was not known for some time, further researches have suggested that they are effective in multiple cellular pathways, as well as pathogenesis of a broad range of diseases including neurodegenerative diseases, cardiovascular diseases, and more importantly, multiple human malignancies. As erstwhile research brought to light more aspects of exosomes' biogenesis and functions, researchers sought to benefit from their effects in therapeutic and diagnostic purposes. Gene therapy is one of these fields that has seen many endeavors made. The present review article looks at gene therapy and its latest advancements, structure and function of exosomes and their role as bio shuttles in various clinical contexts relating to gene therapy.

引用

页码：158 / 170

页数：13

共 216 条

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