Synthesis, anti-inflammatory and antinociceptive activity of some novel benzothiazole derivatives

被引：13
|
作者：
Abbas, Eman M. H. [1 ]
Amin, Kamelia M. [2 ]
El-Hamouly, Wageeh S. [1 ]
Dawood, Dina H. [1 ]
Abdalla, Mohamed M. [3 ]
机构：
[1] Natl Res Ctr, Dept Chem Nat & Microbial Prod, Giza, Egypt
[2] Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt
[3] Saco Pharm Co, Res Unit, Giza, Egypt
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2015年 / 41卷 / 04期
关键词：
Benzothiazol-2-one; Benzothiazole; Anti-inflammatory; Antinocicepative; ANTIMICROBIAL ACTIVITY; AGENTS;
D O I：
10.1007/s11164-013-1367-x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new series of derivatives bearing benzothiazol-2-one or benzothiazole ring system conjugated to other different heterocycles were prepared using 5,6-dimethoxy-3-benzothiazol-2(3H)-one (1) as a starting material. The structures of the newly synthesized products have been established based on analytical and spectral data. In addition, the anti-inflammatory and antinociceptive activities of some of the products were evaluated. Our data showed that many derivatives have promising activities as anti-inflammatory and antinocicepative agents.
引用
收藏
页码：2537 / 2555
页数：19
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