The Neuronal Glutamate Transporter EAAT3 in Obsessive-Compulsive Disorder

被引：16

作者：

Escobar, Angelica P. ^{[1
]}

Wendland, Jens R. ^{[1
]}

Chavez, Andres E. ^{[1
]}

Moya, Pablo R. ^{[1
,2
]}

机构：

[1] Univ Valparaiso, Fac Ciencias, CINV, Valparaiso, Chile

[2] Univ Valparaiso, Inst Fisiol, Fac Ciencias, Valparaiso, Chile

来源：

FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷

关键词：

EAAT3; OCD; obsessive-compulsive disorder; glutamate transporter; synaptic function; NMDAR; animal model; TRANSIENT CEREBRAL-ISCHEMIA; FAMILY-BASED ASSOCIATION; GENOME-WIDE ASSOCIATION; GENE SLC1A1; RILUZOLE AUGMENTATION; CYSTEINE UPTAKE; VOLUMETRIC MRI; GABA SYNTHESIS; BRAIN-REGIONS; ANIMAL-MODEL;

D O I：

10.3389/fphar.2019.01362

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Obsessive compulsive disorder (OCD) is a heterogeneous psychiatric disorder affecting 1%-3% of the population worldwide. About half of OCD afflicted individuals do not respond to currently available pharmacotherapy, which is mainly based on serotonin reuptake inhibition. Therefore, there is a critical need to search novel and improved therapeutic targets to treat this devastating disorder. In recent years, accumulating evidence has supported the glutamatergic hypothesis of OCD, and particularly pointing a potential role for the neuronal glutamate transporter EAAT3. This mini-review summarizes recent findings regarding the neurobiological basis of OCD, with an emphasis on the glutamatergic neurotransmission and EAAT3 as a key player in OCD etiology.

引用

页数：9

共 125 条

[21] Management of obsessive compulsive disorder [J].

Bouvard, MA ;

Milliery, M ;

Cottraux, J .

PSYCHOTHERAPY AND PSYCHOSOMATICS, 2004, 73 (03) :149-157

[22]

Brennan Brian P, 2016, Biol Psychiatry Cogn Neurosci Neuroimaging, V1, P116

[23] Striatal circuits, habits, and implications for obsessive-compulsive disorder [J].

Burguiere, Eric ;

Monteiro, Patricia ;

Mallet, Luc ;

Feng, Guoping ;

Graybiel, Ann M. .

CURRENT OPINION IN NEUROBIOLOGY, 2015, 30 :59-65

[24] Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors [J].

Burguiere, Eric ;

Monteiro, Patricia ;

Feng, Guoping ;

Graybiel, Ann M. .

SCIENCE, 2013, 340 (6137) :1243-1246

[25] Glutamate transporter type 3 regulates mouse hippocampal GluR1 trafficking [J].

Cao, Jiangbei ;

Tan, Hongying ;

Mi, Weidong ;

Zuo, Zhiyi .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2014, 1840 (06) :1640-1645

[26] Glutamatergic dysfunction in OCD [J].

Chakrabarty, K ;

Bhattacharyya, S ;

Christopher, R ;

Khanna, S .

NEUROPSYCHOPHARMACOLOGY, 2005, 30 (09) :1735-1740

[27] Correlation between lipid peroxidation-induced TBARS level and disease severity in obsessive-compulsive disorder [J].

Chakraborty, Sutirtha ;

Singh, Om Prakash ;

Dasgupta, Anindya ;

Mandal, Nikhiles ;

Das, Harendra Nath .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2009, 33 (02) :363-366

[28] Decreased cysteine uptake by EAAC1 gene deletion exacerbates neuronal oxidative stress and neuronal death after traumatic brain injury [J].

Choi, Bo Young ;

Kim, In Yeol ;

Kim, Jin Hee ;

Lee, Bo Eun ;

Lee, Song Hee ;

Kho, A. Ra ;

Jung, Hee Jae ;

Sohn, Min ;

Song, Hong Ki ;

Suh, Sang Won .

AMINO ACIDS, 2016, 48 (07) :1619-1629

[29] EAAC1 Gene Deletion Increases Neuronal Death and Blood Brain Barrier Disruption after Transient Cerebral Ischemia in Female Mice [J].

Choi, Bo Young ;

Kim, Jin Hee ;

Kim, Hyun Jung ;

Lee, Bo Eun ;

Kim, In Yeol ;

Sohn, Min ;

Suh, Sang Won .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (11) :19444-19457

[30] Redox modulation of the NMDA receptor [J].

Choi, YB ;

Lipton, SA .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2000, 57 (11) :1535-1541

← 1 2 3 4 5 6 7 8 9 10 →