The Neuronal Glutamate Transporter EAAT3 in Obsessive-Compulsive Disorder

被引：16
作者：
Escobar, Angelica P. [1 ]
Wendland, Jens R. [1 ]
Chavez, Andres E. [1 ]
Moya, Pablo R. [1 ,2 ]
机构：
[1] Univ Valparaiso, Fac Ciencias, CINV, Valparaiso, Chile
[2] Univ Valparaiso, Inst Fisiol, Fac Ciencias, Valparaiso, Chile
来源：
FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷
关键词：
EAAT3; OCD; obsessive-compulsive disorder; glutamate transporter; synaptic function; NMDAR; animal model; TRANSIENT CEREBRAL-ISCHEMIA; FAMILY-BASED ASSOCIATION; GENOME-WIDE ASSOCIATION; GENE SLC1A1; RILUZOLE AUGMENTATION; CYSTEINE UPTAKE; VOLUMETRIC MRI; GABA SYNTHESIS; BRAIN-REGIONS; ANIMAL-MODEL;
D O I：
10.3389/fphar.2019.01362
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Obsessive compulsive disorder (OCD) is a heterogeneous psychiatric disorder affecting 1%-3% of the population worldwide. About half of OCD afflicted individuals do not respond to currently available pharmacotherapy, which is mainly based on serotonin reuptake inhibition. Therefore, there is a critical need to search novel and improved therapeutic targets to treat this devastating disorder. In recent years, accumulating evidence has supported the glutamatergic hypothesis of OCD, and particularly pointing a potential role for the neuronal glutamate transporter EAAT3. This mini-review summarizes recent findings regarding the neurobiological basis of OCD, with an emphasis on the glutamatergic neurotransmission and EAAT3 as a key player in OCD etiology.
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页数：9
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