Effect of alcohol consumption, cigarette smoking and flushing response on esophageal cancer risk: A population-based cohort study (JPHC study)

被引：121

作者：

Ishiguro, Seiji ^{[1
,2
]}

Sasazuki, Shizuka ^{[1
]}

Inoue, Manami ^{[1
]}

Kurahashi, Norie ^{[1
]}

Iwasaki, Motoki ^{[1
]}

Tsugane, Shoichiro ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Ctr Canc Prevent & Screening, Epidemiol & Prevent Div, Tokyo 104, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Surg, Div Surg Oncol, Nagoya, Aichi 4648601, Japan

来源：

CANCER LETTERS | 2009年 / 275卷 / 02期

关键词：

Alcohol consumption; Cigarette smoking; Flushing; Esophageal squamous cell cancer; Population-based cohort study; SQUAMOUS-CELL CARCINOMA; UPPER AERODIGESTIVE TRACT; ALDEHYDE DEHYDROGENASE; JAPANESE MEN; GENETIC POLYMORPHISMS; DRINKING; ETHANOL; GENOTYPES; TOBACCO; ALDH2;

D O I：

10.1016/j.canlet.2008.10.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined the effect of alcohol consumption, cigarette smoking and flushing response on esophageal squamous cell carcinoma (ESCC) in a large-scale population-based cohort study. 44,970 middle-aged and older Japanese men were followed. A total of 215 cases of ESCC were newly diagnosed. Alcohol consumption and cigarette smoking are strongly associated with the incidence of ESCC. Heavy alcohol consumption increased the risk of ESCC especially among heavy smokers with the flushing response (HR = 3.41, 95% Cl = 2.10-5.51). Strong effect modification was detected in heavy smokers. Our results suggest that heavy alcohol consumption together with heavy smoking may increase the risk of ESCC particularly in individuals with the flushing response. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：240 / 246

页数：7

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