Calcitonin Gene-Related Peptide (CGRP) and Migraine Current Understanding and State of Development

被引：133

作者：

Bigal, Marcelo E. ^{[1
]}

Walter, Sarah ^{[2
]}

Rapoport, Alan M. ^{[3
]}

机构：

[1] Labrys Biol Inc, San Mateo, CA 94404 USA

[2] Labrys Biol Inc, Preclin Res, San Mateo, CA 94404 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA 90095 USA

来源：

HEADACHE | 2013年 / 53卷 / 08期

关键词：

calcitonin gene-related peptide; antibodies; migraine; chronic migraine; RANDOMIZED CONTROLLED-TRIAL; ISOLATED CORONARY-ARTERY; MENINGEAL BLOOD-FLOW; RECEPTOR ANTAGONIST; SUBSTANCE-P; SPINAL-CORD; BRAIN-STEM; ALPHA-CGRP; BETA-CGRP; EXTRACEREBRAL CIRCULATION;

D O I：

10.1111/head.12179

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Calcitonin gene-related peptide (CGRP) is a ubiquitous neuropeptide found at the very centers of the migraine process, both centrally and peripherally. It has been under careful study for approximately 25 years. Several CGRP-receptor antagonists are being evaluated for acute treatment of episodic migraine. Three monoclonal antibodies are being studied for prevention of episodic migraine, and 1 monoclonal antibody is being studied for prevention of chronic migraine. In this review, we discuss the role of CGRP in normal physiology and the consequences of CGRP inhibition for human homeostasis. We then review the current state of development for CGRP-receptor antagonists and CGRP monoclonal antibodies. We close by speculating on the potential clinical role of CGRP antagonism in the acute and preventive treatment of episodic and chronic migraine.

引用

页码：1230 / 1244

页数：15

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